Evidence map›Paper›PMID 41746006›Full record

ArticleTropical medicine and infectious disease2026

AI-Driven Tuberculosis Hotspot Mapping to Optimize Active Case-Finding: Implementing the Epi-Control Platform in Uganda.

Geofrey Amanya, Sumbul Hashmi, Jessica Sarah Stow, Philip Tumwesigye, Bernadette Nkhata, Kelvin Roland Mubiru, Anne-Laure Budts, Matthys Gerhardus Potgieter, Seyoum Dejene Balcha, Muzamiru Bamuloba and 4 more

Abstract read
In one paragraph

Article in Tropical medicine and infectious disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Geofrey AmanyaMinistry of Health Uganda, Lourdel Road, Plot 6, Lourdel Road, Nakasero, Kampala P.O. Box 7272, Uganda.ORCID 0000-0001-5269-5033
Sumbul HashmiEPCON, Lange Gasthuisstraat 29/31, B-2000 Antwerp, Belgium.ORCID 0000-0002-3563-4359
Jessica Sarah StowEPCON, Workshop 17, 146 Campground Rd, 3rd Floor, Snakepit Building, Newlands, Cape Town 7780, South Africa.
Philip TumwesigyeLPHS-TB and Urban Health Activity, Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala P.O. Box 22418, Uganda.
Bernadette NkhataEPCON, Workshop 17, 146 Campground Rd, 3rd Floor, Snakepit Building, Newlands, Cape Town 7780, South Africa.
Kelvin Roland MubiruLPHS-TB and Urban Health Activity, Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala P.O. Box 22418, Uganda.ORCID 0000-0001-8647-2399
Anne-Laure BudtsEPCON, Lange Gasthuisstraat 29/31, B-2000 Antwerp, Belgium.
Matthys Gerhardus PotgieterEPCON, Workshop 17, 146 Campground Rd, 3rd Floor, Snakepit Building, Newlands, Cape Town 7780, South Africa.ORCID 0000-0002-9919-9210
Seyoum Dejene BalchaMinistry of Health Uganda, Lourdel Road, Plot 6, Lourdel Road, Nakasero, Kampala P.O. Box 7272, Uganda.
Muzamiru BamulobaMinistry of Health Uganda, Lourdel Road, Plot 6, Lourdel Road, Nakasero, Kampala P.O. Box 7272, Uganda.
Andiswa ZithoEPCON, Workshop 17, 146 Campground Rd, 3rd Floor, Snakepit Building, Newlands, Cape Town 7780, South Africa.
Luzze HenryMinistry of Health Uganda, Lourdel Road, Plot 6, Lourdel Road, Nakasero, Kampala P.O. Box 7272, Uganda.
Mary G Nabukenya-MudiopeLPHS-TB and Urban Health Activity, Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala P.O. Box 22418, Uganda.ORCID 0009-0003-9041-3684
Caroline Van CauwelaertEPCON, Lange Gasthuisstraat 29/31, B-2000 Antwerp, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculosis remains a major public health concern in Uganda, one among the thirty high TB burden countries globally. Despite national progress, gaps persist due to asymptomatic disease, diagnostic limitations, and uneven access to healthcare within the country. This study implemented the Epi-control platform, an AI-driven predictive modelling tool, to predict community-level hotspots and support data-driven active case-finding (ACF). Using retrospective chest X-ray screening data, we integrated demographic, environmental, and human development indicators from open-source databases to model TB risk at sub-parish level. A proprietary Bayesian modelling framework was deployed and validated by comparing TB yields between predicted hotspots and non-hotspot locations. Across Uganda, the model identified significantly higher TB yields in hotspot areas (risk ratio = 1.69, 95% CI 1.41-2.02;

Indexed as

active case-findingartificial intelligencehotspotstuberculosis

Identifiers

PMID41746006
PMCPMC12945205

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.