Evidence map›Paper›PMID 41745983›Full record

ArticleVeterinary sciences2026

Hydroxycinnamic and Hydroxybenzoic-Based Mitochondriotropic Antioxidants Improve Bovine Embryo Quality and Cryo-Survival.

Filipa Ferreira, Beatriz Lourenço, José Teixeira, Fernando Cagide, Sofia Benfeito, Fernando Lidon, Fernanda Borges, Paulo J Oliveira, Rosa M Lino Neto Pereira

Abstract read
In one paragraph

Article in Veterinary sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Filipa FerreiraINIAV-Instituto Nacional de Investigação Agrária e Veterinária, Unidade de Biotecnologia e Recursos Genéticos, Quinta da Fonte Boa, 2005-048 Vale de Santarém, Portugal.ORCID 0009-0005-5385-4012
Beatriz LourençoINIAV-Instituto Nacional de Investigação Agrária e Veterinária, Unidade de Biotecnologia e Recursos Genéticos, Quinta da Fonte Boa, 2005-048 Vale de Santarém, Portugal.
José TeixeiraCNC UC-Center for Neuroscience and Cell Biology, University of Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0003-0834-5698
Fernando CagideMedInUP, Center for Drug Discovery and Innovative Medicines, Department of Biomedicine, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.ORCID 0000-0001-9410-6874
Sofia BenfeitoMedInUP, Center for Drug Discovery and Innovative Medicines, Department of Biomedicine, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.
Fernando LidonGeobiotec, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal.
Fernanda BorgesMedInUP, Center for Drug Discovery and Innovative Medicines, Department of Biomedicine, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.ORCID 0000-0003-1050-2402
Paulo J OliveiraCNC UC-Center for Neuroscience and Cell Biology, University of Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0002-5201-9948
Rosa M Lino Neto PereiraINIAV-Instituto Nacional de Investigação Agrária e Veterinária, Unidade de Biotecnologia e Recursos Genéticos, Quinta da Fonte Boa, 2005-048 Vale de Santarém, Portugal.ORCID 0000-0002-7514-6130

Funding

European HORIZON Project Cryostore number: 101120454Fundação para a Ciência e Tecnologia LA/P/0059/2020 (AL4AnimalS)Fundação para a Ciência e Tecnologia UIDB/50006/2020, UID/CVT/0027/2020 (CIISA), EXPL/BIA-BQM/1361/2021
6 · The paper itself

Abstract

Assisted reproductive technologies (ART) use has increased over the past decades. However, reports concerning ART's low efficiency continue to emerge, citing causes related to lower embryo quality and pregnancy rates compared to their in vivo counterparts. One of the setbacks of ART is oxidative stress, which can impair embryo developmental rates. Mitochondrial redox and energetic homeostasis determine both cell survival and death, so mitochondria are a key target for therapeutic intervention strategies. In the present work, our objective was to improve the quality of viable embryos by adding new mitochondria-targeted antioxidants in the embryo culture media to reduce oxidative stress. Two naturally derived antioxidants synthesized by our team, AntiOxBEN

Indexed as

assisted reproductive technologies (ART)embryonic developmentmitochondria-targeted antioxidantsoxidative stressROS

Identifiers

PMID41745983
PMCPMC12945204

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.