Evidence map›Paper›PMID 41745835›Full record

ArticleToxics2026

Caffeine Exposure Modulates Trophoblast Differentiation and Estradiol Synthesis.

Jihyun Keum, Jeonghyeon Lee, Ki-Young Ryu, Jaesook Roh

Abstract read
In one paragraph

Article in Toxics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jihyun KeumDepartment of Obstetrics & Gynecology, College of Medicine, Hanyang University, Seoul 133-791, Republic of Korea.ORCID 0000-0002-2032-0971
Jeonghyeon LeeDepartment of Anatomy & Cell Biology, College of Medicine, Hanyang University, Seoul 133-791, Republic of Korea.
Ki-Young RyuDepartment of Obstetrics & Gynecology, College of Medicine, Hanyang University, Seoul 133-791, Republic of Korea.
Jaesook RohDepartment of Anatomy & Cell Biology, College of Medicine, Hanyang University, Seoul 133-791, Republic of Korea.ORCID 0000-0002-6286-1071

Funding

Hanyang University HY-2025
6 · The paper itself

Abstract

Differentiation of villous cytotrophoblasts into syncytiotrophoblasts is essential for placental endocrine function and estradiol production. Caffeine consumption has been linked to altered estradiol levels, but its effects on human trophoblast differentiation remain incompletely understood. This study investigated the effects of caffeine on biochemical differentiation of human trophoblasts using BeWo cells and human placental explants. Cell viability and apoptosis were assessed using CCK-8 and in situ TUNEL assays. Differentiation-associated changes were evaluated by measuring

Indexed as

caffeineCYP19A1estrogenPKA pathwaytrophoblast differentiation

Identifiers

PMID41745835
PMCPMC12945251

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.