Evidence map›Paper›PMID 41745735›Full record

ReviewToxins2026

Exploring the Pain-Relieving Potential: Unveiling Antinociceptive Properties in Animal Venoms and Toxins.

Davi Gomes Angstmam, Bruna Cristina Jeronimo, Joeliton Dos Santos Cavalcante, Ana Flávia Marques Pereira, Cristiane Flora Villarreal, Daniel Carvalho Pimenta, Rui Seabra Ferreira Junior

Abstract readReview
In one paragraph

Review in Toxins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Davi Gomes AngstmamBotucatu Medical School (FMB), São Paulo State University (UNESP-Universidade Estadual Paulista), Botucatu 18618-687, SP, Brazil.ORCID 0000-0003-1765-1304
Bruna Cristina JeronimoBotucatu Medical School (FMB), São Paulo State University (UNESP-Universidade Estadual Paulista), Botucatu 18618-687, SP, Brazil.ORCID 0000-0002-1741-3341
Joeliton Dos Santos CavalcanteBotucatu Medical School (FMB), São Paulo State University (UNESP-Universidade Estadual Paulista), Botucatu 18618-687, SP, Brazil.ORCID 0000-0001-5712-9137
Ana Flávia Marques PereiraBotucatu Medical School (FMB), São Paulo State University (UNESP-Universidade Estadual Paulista), Botucatu 18618-687, SP, Brazil.ORCID 0000-0002-2925-8545
Cristiane Flora VillarrealLaboratory of Pharmacology and Therapeutic (LAFTE), University Federal of Bahia (UFBA), Salvador 40170-290, BA, Brazil.ORCID 0000-0002-0113-7864
Daniel Carvalho PimentaLaboratório de Ecologia e Evolução, Butantan Institute, São Paulo 05503-900, SP, Brazil.ORCID 0000-0003-2406-0860
Rui Seabra Ferreira JuniorBotucatu Medical School (FMB), São Paulo State University (UNESP-Universidade Estadual Paulista), Botucatu 18618-687, SP, Brazil.ORCID 0000-0001-6952-0512

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/11936-3
6 · The paper itself

Abstract

Currently, commercially available pain medications can cause adverse effects. Within this framework, researchers have been exploring new drug candidates derived from animal venoms and toxins. The objective of this study was to investigate the number of molecules with potential for pain relief derived from animal venoms and toxins, which could potentially contribute to the development of new biopharmaceuticals. We conducted a literature search in January 2025, covering the period from 1960 to 2025, in two Latin American and nine international scientific databases. The results consisted of 212 articles selected for review. From these articles, 152 toxins and venoms with analgesic potential were identified and classified into 14 different types of pharmacological targets. The peptides investigated, with masses between 500 Da and 5000 Da, are strong candidates for alternative biopharmaceuticals. Most of the toxins found interact with ion channels, representing an alternative to commercially available drugs.

Indexed as

antinociceptivenociceptorspaintherapeutic moleculestoxins

Identifiers

PMID41745735
PMCPMC12945304

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.