Evidence map›Paper›PMID 41745627›Full record

ArticleMetabolites2026

Unveiling the Antidiabetic Potential of

Alexis Emus Medina, Cress L Santos-Ballardo, Carlos B Castro-Tamayo, Ramón I Castillo-López, Miguel A Angulo-Escalante, Jesús J Portillo-Loera, J Basilio Heredia

Abstract read
In one paragraph

Article in Metabolites, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alexis Emus MedinaPh.D. Program in Agricultural Sciences, Faculty of Veterinary Medicine and Zootechnics, Autonomous University of Sinaloa, Blvd. San Ángel 3886, Predio Las Coloradas, Culiacán 80260, Sinaloa, Mexico.ORCID 0000-0002-0656-825X
Cress L Santos-BallardoFaculty of Biology, Autonomous University of Sinaloa, Calzada de las Américas, Blvd. Universitario, Cd. Universitaria, Culiacán 80040, Sinaloa, Mexico.ORCID 0000-0002-6918-7331
Carlos B Castro-TamayoPh.D. Program in Agricultural Sciences, Faculty of Veterinary Medicine and Zootechnics, Autonomous University of Sinaloa, Blvd. San Ángel 3886, Predio Las Coloradas, Culiacán 80260, Sinaloa, Mexico.
Ramón I Castillo-LópezFaculty of Chemical-Biological Sciences, Autonomous University of Sinaloa, Calzada de las Américas, Blvd. Universitario, Cd. Universitaria, Culiacán 80040, Sinaloa, Mexico.ORCID 0000-0003-1494-7863
Miguel A Angulo-EscalanteResearch Center for Food and Development, A.C. (CIAD), Carretera a Eldorado Km 5.5, Col. Campo el Diez, Culiacán 80110, Sinaloa, Mexico.
Jesús J Portillo-LoeraPh.D. Program in Agricultural Sciences, Faculty of Veterinary Medicine and Zootechnics, Autonomous University of Sinaloa, Blvd. San Ángel 3886, Predio Las Coloradas, Culiacán 80260, Sinaloa, Mexico.
J Basilio HerediaResearch Center for Food and Development, A.C. (CIAD), Carretera a Eldorado Km 5.5, Col. Campo el Diez, Culiacán 80110, Sinaloa, Mexico.ORCID 0000-0003-1017-957X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectives

methodsTotal phenolic and flavonoid contents were determined, and antioxidant capacity was evaluated using different assays. Phenolic acids were tentatively identified by UPLC-qTOF-MS/MS. Enzyme inhibition assays against α-glucosidase and α-amylase were performed in vitro, and molecular docking was used to explore enzyme-ligand interactions.

resultsThe total phenolic content was significantly higher in the fruit (552.9 mg GAE/100 g dw), while flavonoids were more abundant in leaves (119.84 mg QE/100 g dw). Antioxidant capacity varied among plant parts, depending on the assay used. Caffeic, chlorogenic, coumaric, ferulic, gallic, and quinic acids were identified. The highest concentrations were observed for chlorogenic, ferulic, and quinic acids. Among the analyzed parts, leaf extracts showed the most potent inhibitory effect on α-glucosidase (IC

conclusionsThese results suggest that

Indexed as

bioactive compoundscuajilotemedicinal plantmolecular dockingParmentiera edulisphytochemical analysisplant extractα-amylase inhibitionα-glucosidase inhibition

Identifiers

PMID41745627
PMCPMC12943661

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.