ArticleMetabolites2026
Circulating Gremlin-1 Reflects Age-Associated Metabolic Changes in Women.
Article in Metabolites, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
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Authors and funding
2 authors.
Funding
Abstract
backgroundMenopause is accompanied by hormonal alterations that are closely linked to changes in body composition, insulin sensitivity, and cardiovascular risk in women. Gremlin-1 has recently been identified as an adipokine involved in metabolic and reproductive aging; however, its associations with endocrine and lipid biomarkers across the menopausal transition remain incompletely defined.
objectivesTo evaluate the relationships between plasma Gremlin-1 and IGF-1, HDL cholesterol, estradiol, and age in reproductive-aged and postmenopausal women.
methodsThis cross-sectional study included 88 women aged 18-65 years, stratified by menopausal status (reproductive-aged vs. postmenopausal). Plasma concentrations of Gremlin-1, growth hormone, IGF-1, insulin, estradiol (E2), glucose, HbA1c, and a standard lipid profile were measured.
resultsPlasma Gremlin-1 concentrations were significantly higher in postmenopausal women compared with reproductive-aged women (
conclusionCirculating Gremlin-1 primarily reflects chronological aging and associated endocrine-metabolic changes rather than menopausal status or adiposity per se. While unadjusted associations with metabolic biomarkers are detectable, these relationships are largely attributable to aging. Gremlin-1 may therefore serve as a marker of systemic aging-related endocrine-metabolic remodeling rather than a specific indicator of ovarian aging or adipose tissue dysfunction.
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