ArticleJournal of functional biomaterials2026
Application of Fibrin-Laminin Hydrogel Concurrent with Electrically Stimulated Eccentric Training Hinders Recovery in Volumetric Muscle Loss.
Article in Journal of functional biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Protein-Encoding Chemically Modified mRNAs for Musculoskeletal Tissue Regeneration and Repair.Journal of functional biomaterials · 2026Review
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Authors and funding
6 authors.
Funding
Abstract
Regenerative rehabilitation can enhance skeletal muscle recovery following trauma-induced volumetric muscle loss (VML). We previously optimized fibrin-laminin hydrogels for muscle regeneration and an electrically stimulated eccentric contraction training (EST) for muscle rehabilitation. The goal of this study was to examine the combined effect of these two therapies on maximizing tissue recovery. A VML defect was created by removing ~20% of muscle mass from the tibialis anterior (TA) muscle in adult male Lewis rats. The injured TA muscles were treated with fibrin-laminin (FBN450) hydrogel. EST was implemented 2 weeks post-injury at both 100 Hz and 150 Hz frequencies and continued for 4 weeks. The results showed no improvement in muscle mass or function with combined FBN450 and EST application. Histological analysis revealed significantly reduced type 2B myofiber cross-sectional area (CSA) and percentage in the combined hydrogel and EST treatment group. Gene expression studies showed >20-fold higher inflammatory (e.g., CCR7, CD163) and fibrotic (e.g., Col1a1) signaling, with no concomitant increase in myogenic markers in the hydrogel + EST group. Collectively, these results indicate that the FBN450 hydrogel therapy did not synergize with EST to improve outcomes following VML.
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