Evidence map›Paper›PMID 41745485›Full record

ArticleMarine drugs2026

Integrative Metabolomics and Systems Pharmacology Reveal PPARγ-Centered Antidiabetic Mechanisms of

Fahrul Nurkolis, Annette d'Arqom, Evhy Apryani, Nurmawati Fatimah, Adha Fauzi Hendrawan, Izza Afkarina, Reggie Surya, Happy Kurnia Permatasari, Dante Saksono Harbuwono, Nurpudji Astuti Taslim and 2 more

Abstract read
In one paragraph

Article in Marine drugs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fahrul NurkolisMaster Program of Basic Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya 60131, Indonesia.ORCID 0000-0003-2151-0854
Annette d'ArqomDepartment of Anatomy, Histology, and Pharmacology, Faculty of Medicine, Universitas Airlangga, Surabaya 60131, Indonesia.ORCID 0000-0002-5412-9913
Evhy ApryaniDepartment of Anatomy, Histology, and Pharmacology, Faculty of Medicine, Universitas Airlangga, Surabaya 60131, Indonesia.ORCID 0009-0009-1842-9714
Nurmawati FatimahDepartment of Anatomy, Histology, and Pharmacology, Faculty of Medicine, Universitas Airlangga, Surabaya 60131, Indonesia.
Adha Fauzi HendrawanDepartment of Medicine, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.ORCID 0009-0004-9222-1173
Izza AfkarinaCorpora Science Research Laboratory, Yogyakarta 55223, Indonesia.
Reggie SuryaDepartment of Food Technology, Faculty of Engineering, Bina Nusantara University, Jakarta 11480, Indonesia.ORCID 0000-0002-8165-2072
Happy Kurnia PermatasariDepartment of Biochemistry and Biomolecular, Faculty of Medicine, Brawijaya University, Malang 65145, Indonesia.ORCID 0000-0002-4777-624X
Dante Saksono HarbuwonoDivision of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta 10430, Indonesia.
Nurpudji Astuti TaslimDivision of Clinical Nutrition, Department of Nutrition, Faculty of Medicine, Hasanuddin University, Makassar 90245, Indonesia.ORCID 0000-0003-1349-5367
Arifa MustikaDepartment of Anatomy, Histology, and Pharmacology, Faculty of Medicine, Universitas Airlangga, Surabaya 60131, Indonesia.ORCID 0000-0001-6461-5782
Raymond Rubianto TjandrawinataSchool of Bioscience, Innovation and Technology, Atma Jaya Catholic University of Indonesia, Jakarta 12930, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder requiring safe, multitarget therapeutic strategies. Marine macroalgae represent an underexplored source of bioactives with pleiotropic metabolic effects. This study investigated the antidiabetic potential of an ultrasound-assisted ethanolic extract of

Indexed as

CaulerpaHypoglycemic AgentsPlant ExtractsPPAR gamma3T3-L1 CellsAdipocytesAnimalsCholesterolDiabetes Mellitus, Type 2Dipeptidyl-Peptidase IV InhibitorsMetabolomicsMiceMolecular Docking SimulationMolecular Dynamics SimulationNetwork PharmacologyPhytosterolscampesterolCholesterolDipeptidyl-Peptidase IV InhibitorsHypoglycemic AgentsPhytosterolsPlant ExtractsPPAR gammacampesterolCaulerpa racemosaDPP-4functional foodglucose uptakemetabolomicsmolecular dockingnetwork pharmacologyPPARγtype 2 diabetes mellitus

Identifiers

PMID41745485
PMCPMC12941865

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.