ArticleJournal of imaging2026
Automated Compactness Quantitative Metrics for Wrist Bone on Conventional Radiography in Rheumatoid Arthritis: A Clinical Evaluation Study.
Article in Journal of imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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7 authors.
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Abstract
Rheumatoid arthritis (RA) frequently affects the joints of the hands, with joint space narrowing (JSN) representing an important early marker of structural damage. The semi-quantitative Sharp/van der Heijde (SvdH) scoring system is widely used in clinical practice but is inherently subjective and susceptible to observer variability. Moreover, the complex anatomy of the wrist and substantial overlap of carpal bones pose challenges for automated quantitative assessment of wrist JSN on routine radiographs. This study aimed to introduce a novel quantitative assessment perspective and to clinically validate an automated, compactness-related quantification framework for evaluating wrist JSN in RA. This study initially enrolled 51 patients with RA. After excluding one case with severe carpal fusion that precluded anatomical differentiation, 50 patients (44 females and 6 males) were included in the final analysis. The cohort had a mean age of 61 years (range: 21-82), a median symptom duration of 9 years (IQR: 1-32), and a median follow-up interval for bilateral hand radiographs of 1.06 years (IQR: 0.82-1.30). To quantify global wrist JSN, 10 compactness-related metrics were computed based on the spatial distribution of bone centroids extracted from carpal segmentation masks. These metrics were validated against the wrist JSN subscore of the SvdH score (SvdH-JSN_wrist) and the total Sharp score (TSS) as gold standards. Several distance-based metrics among the compactness-related metrics showed significant negative correlations with the wrist joint space narrowing subscore of the Sharp/van der Heijde score (SvdH-JSN_wrist). Specifically, mean-pairwise-distance (MPD), root-mean-square-radius (RMSR), and median-radius (R50) showed moderate to strong correlations (r = -0.52 to -0.63, all p≤0.0001) that were consistent at BL and FU. Correlations with TSS were weaker overall, with only R50 and its normalized form showing stable negative correlations (r = -0.40 to -0.43,
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