Evidence map›Paper›PMID 41745323›Full record

ArticleJournal of cardiovascular development and disease2026

Cardiac CT Angiography in Diagnosing Patent Foramen Ovale: A Study on Patients with Suspected Patent Foramen Ovale-Associated Stroke.

Lijie Sun, Chong Zheng, Zhenxing Fan, Jing Gao, Zhi Liu, Jin Si, Keling Xiao, Ming Yi, Haoyu Zhang, Jinghao Sun and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular development and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Lijie SunDepartment of Geriatrics, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing 100053, China.ORCID 0000-0002-1389-8169
Chong ZhengDepartment of Radiology and Nuclear Medicine, Xuanwu Hospital Capital Medical University, Beijing 100053, China.
Zhenxing FanDepartment of Geriatrics, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing 100053, China.
Jing GaoDepartment of Cardiology, Xuanwu Hospital Capital Medical University, Beijing 100053, China.
Zhi LiuDepartment of Emergency, Xuanwu Hospital Capital Medical University, Beijing 100053, China.
Jin SiDepartment of Geriatrics, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing 100053, China.
Keling XiaoDepartment of Geriatrics, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing 100053, China.
Ming YiDepartment of Geriatrics, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing 100053, China.
Haoyu ZhangDepartment of Geriatrics, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing 100053, China.
Jinghao SunDepartment of Geriatrics, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing 100053, China.
Yijin LiuDepartment of Radiology and Nuclear Medicine, Xuanwu Hospital Capital Medical University, Beijing 100053, China.
Yang HuaDepartment of Vascular Ultrasound, Xuanwu Hospital Capital Medical University, Beijing 100053, China.
Yingqi XingDepartment of Vascular Ultrasound, Xuanwu Hospital Capital Medical University, Beijing 100053, China.
Jie LuDepartment of Radiology and Nuclear Medicine, Xuanwu Hospital Capital Medical University, Beijing 100053, China.ORCID 0000-0003-0425-3921
Jing LiDepartment of Geriatrics, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing 100053, China.

Funding

This research was funded by the National Natural Science Foundation of China (grant number 82170347) and Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes JYY2023-13
6 · The paper itself

Abstract

backgroundCardiac computed tomographic angiography (CTA) detects patent foramen ovale (PFO) with variable accuracy. This study investigated factors affecting CTA detectability for PFO in patients with suspected PFO-associated stroke.

methodsConsecutive patients with cryptogenic stroke and positive findings on contrast transcranial Doppler (cTCD) examinations were enrolled between November 2020 and April 2023 in this retrospective study. Each participant underwent transesophageal echocardiography (TEE) and cardiac CTA. Patients with confirmed PFO on TEE were categorized into two groups based on CTA detectability: the CTA-positive group (PFO identified by CTA) and the CTA-negative group (PFO missed by CTA). Univariate and multivariate logistic regression analyses were performed to identify predictors of CTA false-negative results.

resultsAmong 108 patients (mean age 46.7 ± 14.9 years, 47.2% male), the prevalence of PFO by TEE was 94.4% (102/108). Compared to TEE, cardiac CTA had a sensitivity of 70% (95% CI 61-79%), a specificity of 100% (95% CI 54-100%), a positive predictive value of 100% (95% CI 95-100%), and a negative predictive value of 16% (95% CI 6-32%). Among patients with PFO confirmed by TEE (

conclusionsCardiac CTA could be an effective complementary modality for selected patients with suspected PFO-associated stroke. Its diagnostic performance appears more reliable for identifying PFO in patients with moderate-to-large RLS than in those with small RLS.

Indexed as

computed tomographic angiographycontrast transcranial Dopplercryptogenic strokepatent foramen ovaletransesophageal echocardiography

Identifiers

PMID41745323
PMCPMC12940995

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