Evidence map›Paper›PMID 41745188›Full record

ArticleNanomaterials (Basel, Switzerland)2026

Development of Biological-Window-Active Au Open-Shell Nanoparticles with High-Sensitivity Surface-Enhanced Raman Scattering Imaging Probe Properties.

Kosuke Sugawa, Yuka Hori, Azusa Onozato, Hikaru Naitoh, Arisa Suzuki, Tamaki Amemiya, Hironobu Tahara, Tsuyoshi Kimura, Yasuhiro Kosuge, Keiji Ohno and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kosuke SugawaDepartment of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Chiyoda 101-8308, Tokyo, Japan.ORCID 0000-0002-3434-4632
Yuka HoriDepartment of Materials and Applied Chemistry, Graduate School of Science and Technology, Nihon University, Chiyoda 101-8308, Tokyo, Japan.
Azusa OnozatoDepartment of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Chiyoda 101-8308, Tokyo, Japan.
Hikaru NaitohDepartment of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Chiyoda 101-8308, Tokyo, Japan.
Arisa SuzukiDepartment of Materials and Applied Chemistry, Graduate School of Science and Technology, Nihon University, Chiyoda 101-8308, Tokyo, Japan.
Tamaki AmemiyaDepartment of Materials and Applied Chemistry, Graduate School of Science and Technology, Nihon University, Chiyoda 101-8308, Tokyo, Japan.
Hironobu TaharaGraduate School of Integrated Science and Technology, Nagasaki University, Bunkyo 1-14, Nagasaki 852-8521, Nagasaki, Japan.ORCID 0000-0001-6229-572X
Tsuyoshi KimuraDepartment of Biomedical Engineering, Faculty of Life Science, Toyo University, 48-1 Oka, Asaka-shi 351-8510, Saitama, Japan.ORCID 0000-0003-0476-0624
Yasuhiro KosugeLaboratory of Pharmacology, School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi 274-8555, Chiba, Japan.ORCID 0000-0002-7513-5132
Keiji OhnoDepartment of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Chiyoda 101-8308, Tokyo, Japan.ORCID 0000-0001-8279-8439
Takeshi HashimotoDepartment of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioi-cho, Chiyoda-ku 102-8554, Tokyo, Japan.ORCID 0000-0002-7601-5511
Takashi HayashitaDepartment of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioi-cho, Chiyoda-ku 102-8554, Tokyo, Japan.ORCID 0000-0003-1264-9694
Joe OtsukiDepartment of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Chiyoda 101-8308, Tokyo, Japan.ORCID 0000-0001-9974-6037

Funding

Grants-in-Aid for Scientific Research 25K01884
6 · The paper itself

Abstract

The development of anisotropic gold nanostructures supporting localized surface plasmon (LSP) resonances in the near-infrared (NIR) biological window is of great interest for diagnostic and therapeutic nanotechnologies. Here, we report gold open-shell nanoparticles (AuOSNs), a symmetry-broken nanoshell architecture exhibiting strong NIR surface-enhanced Raman scattering (SERS) activity. AuOSNs were fabricated via a surfactant-free strategy combining bottom-up silica sphere assembly with a simple top-down gold deposition process, without using highly cytotoxic surfactants such as cetyltrimethylammonium bromide (CTAB). Boundary element method (BEM) simulations revealed that the asymmetric open-shell geometry induces NIR LSP resonances with pronounced electromagnetic field localization near the opening edges, depending on excitation configuration. Consistent with these predictions, extinction spectra of AuOSNs dispersed in water showed an LSP resonance peak at ~793 nm, close to the 785 nm excitation wavelength for SERS. In aqueous dispersion, AuOSNs modified with 4-mercaptobenzoic acid (4-MBA) exhibited strong SERS activity with enhancement factors of ~10

Indexed as

bioimaginglocalized surface plasmonnanoshellsopen-shell nanostructuressurface-enhanced Raman scattering

Identifiers

PMID41745188
PMCPMC12943581

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.