ArticleDiseases (Basel, Switzerland)2026
CD36 rs1761667 Polymorphism and Its Impact on Molecular Signatures in Bladder Cancer.
Article in Diseases (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundBladder cancer remains a heterogeneous disease, and genetic factors are increasingly recognized as potential contributors to its pathogenesis. CD36, a multifunctional scavenger receptor implicated in lipid metabolism and tumor progression, has not been previously investigated in relation to bladder cancer-associated polymorphisms.
objectivesThis study examined the relationship between the rs1761667 variant and CD36 mRNA expression.
methodsOur study included 30 patients with bladder cancer and 19 controls. PCR-RFLP genotyping for rs1761667 and RT-qPCR quantification of CD36 mRNA expression, with GAPDH as the reference gene, were performed. Expression levels were analyzed using the 2
resultsIn patients, CD36 expression varied significantly across rs1761667 genotypes with reduced expression in AA carriers compared with GG carriers (post hoc,
conclusionsThese results indicate that rs1761667 may modulate CD36 transcription in a genotype-dependent manner, particularly in the disease context. Overall, our findings point to a potential biological connection between inherited CD36 variation and bladder cancer-related pathways, underscoring the need for further validation in tumor tissues.
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