Evidence map›Paper›PMID 41744869›Full record

ArticleCurrent oncology (Toronto, Ont.)2026

Primary Renal Neuroendocrine Tumor: Diagnostic Challenges in a Rare Entity-A Case Report.

Raphaela D Lewetag, Katharina Kluthe, Nils F Trautwein, Ulrich M Lauer, Christian la Fougère, Bence Sipos, Lars Zender, Clemens Hinterleitner, Stephan Singer, Martina Hinterleitner

Abstract readCase Reports
In one paragraph

Article in Current oncology (Toronto, Ont.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Raphaela D LewetagDepartment of Medical Oncology and Pneumology (Internal Medicine VIII), University Hospital Tuebingen, 72076 Tuebingen, Germany.ORCID 0009-0001-5892-1879
Katharina KlutheDepartment of Pathology, University Hospital Tuebingen, 72076 Tuebingen, Germany.
Nils F TrautweinENETS Center of Excellence, University Hospital Tuebingen, 72076 Tuebingen, Germany.ORCID 0000-0003-3397-6299
Ulrich M LauerDepartment of Medical Oncology and Pneumology (Internal Medicine VIII), University Hospital Tuebingen, 72076 Tuebingen, Germany.ORCID 0000-0002-4557-7730
Christian la FougèreENETS Center of Excellence, University Hospital Tuebingen, 72076 Tuebingen, Germany.ORCID 0000-0001-7519-0417
Bence SiposDepartment of Medical Oncology and Pneumology (Internal Medicine VIII), University Hospital Tuebingen, 72076 Tuebingen, Germany.
Lars ZenderDepartment of Medical Oncology and Pneumology (Internal Medicine VIII), University Hospital Tuebingen, 72076 Tuebingen, Germany.
Clemens HinterleitnerDepartment of Medical Oncology and Pneumology (Internal Medicine VIII), University Hospital Tuebingen, 72076 Tuebingen, Germany.
Stephan SingerENETS Center of Excellence, University Hospital Tuebingen, 72076 Tuebingen, Germany.
Martina HinterleitnerDepartment of Medical Oncology and Pneumology (Internal Medicine VIII), University Hospital Tuebingen, 72076 Tuebingen, Germany.ORCID 0000-0001-7137-0541

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy-EXC 2180-390900677 EXC 2180-390900677NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Neuroendocrine neoplasms (NENs) represent a rare, heterogeneous group of malignancies. Within this tumor entity, primary renal neuroendocrine tumors (PRNETs) are exceedingly rare, with only 160 cases reported worldwide. Due to the absence of native neuroendocrine cells in the renal parenchyma, their cellular origin remains unclear. Clinical and diagnostic challenges are reflected by the low incidence, non-specific clinical presentation, resemblance to common renal neoplasms, and the need for specialized histopathological diagnostic examination. Here, we present the case of a 61-year-old female with an incidentally diagnosed left-sided PRNET in September 2024. This case highlights the diagnostic complexity of PRNET and, importantly, underscores its genomic heterogeneity. It demonstrates a lack of typical renal cell carcinoma (RCC) or common NEN-associated gene alterations, emphasizing their unique molecular landscape.

Indexed as

Kidney NeoplasmsNeuroendocrine TumorsFemaleHumansMiddle Agedimmunohistochemistryneuroendocrine neoplasmsprimary renal neuroendocrine tumorSSTR PETtumor genome sequencing

Identifiers

PMID41744869
PMCPMC12939182

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.