Evidence map›Paper›PMID 41744743›Full record

ArticleBiosensors2026

A Suspended Graphene Field-Effect Transistor for Ultra-Sensitive and Label-Free Detection of Cancer Biomarker miR-21.

Zhiming Deng, Cong Zeng, Qihang Wu, Fumin Zhang, Pingping Zhuang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhiming DengFujian Provincial Key Laboratory of Oceanic Information Perception and Intelligent Processing, School of Ocean Information Engineering, Jimei University, Xiamen 361021, China.
Cong ZengFujian Provincial Key Laboratory of Oceanic Information Perception and Intelligent Processing, School of Ocean Information Engineering, Jimei University, Xiamen 361021, China.
Qihang WuFujian Provincial Key Laboratory of Oceanic Information Perception and Intelligent Processing, School of Ocean Information Engineering, Jimei University, Xiamen 361021, China.
Fumin ZhangFujian Provincial Key Laboratory of Oceanic Information Perception and Intelligent Processing, School of Ocean Information Engineering, Jimei University, Xiamen 361021, China.
Pingping ZhuangFujian Provincial Key Laboratory of Oceanic Information Perception and Intelligent Processing, School of Ocean Information Engineering, Jimei University, Xiamen 361021, China.

Funding

Pingping Zhuang ZRCY2025003
6 · The paper itself

Abstract

The sensitive detection of microRNA-21 (miR-21), a key biomarker for various cancers, is crucial for early diagnosis, yet conventional methods often face limitations in sensitivity and operational complexity. Here, we report a label-free biosensor based on a suspended graphene field-effect transistor (GFET) for the direct electrical detection of miR-21. The suspended architecture isolates the graphene channel from substrate-induced interference, resulting in enhanced carrier mobility and reduced electrical noise. After surface functionalization with a specific probe, the GFET demonstrated a clear concentration-dependent response to target miR-21. The binding events were transduced into a monotonic increase in relative resistance (ΔR/R

Indexed as

cancer biomarkerfield-effect transistor (FET) biosensorlabel-free detectionmicro RNAsuspended graphene

Identifiers

PMID41744743
PMCPMC12937835

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.