Evidence map›Paper›PMID 41744681›Full record

ArticlemBio2026

G521 is the gatekeeper and a key transmembrane domain contact residue of

Mengcun Zhao, Masakazu Niimi, Kyoko Niimi, Ariya Chindamporn, Susumu Kajiwara, Michele Bonus, Holger Gohlke, Lutz Schmitt, Joel D A Tyndall, Richard D Cannon and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mengcun ZhaoFaculty of Dentistry, Sir John Walsh Research Institute, University of Otago, Dunedin, New Zealand.ORCID 0009-0006-2360-8854
Masakazu NiimiFaculty of Dentistry, Sir John Walsh Research Institute, University of Otago, Dunedin, New Zealand.
Kyoko NiimiFaculty of Dentistry, Sir John Walsh Research Institute, University of Otago, Dunedin, New Zealand.
Ariya ChindampornMycology Unit, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.ORCID 0000-0002-9761-1670
Susumu KajiwaraSchool of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.
Michele BonusInstitute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID 0000-0003-4411-7342
Holger GohlkeInstitute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID 0000-0001-8613-1447
Lutz SchmittInstitute of Biochemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID 0000-0002-1167-9819
Joel D A TyndallSchool of Pharmacy, University of Otago, Dunedin, New Zealand.ORCID 0000-0003-0783-1635
Richard D CannonFaculty of Dentistry, Sir John Walsh Research Institute, University of Otago, Dunedin, New Zealand.ORCID 0000-0002-5398-2066
Erwin LampingFaculty of Dentistry, Sir John Walsh Research Institute, University of Otago, Dunedin, New Zealand.ORCID 0000-0002-4942-4782

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IMPORTANCE:

Indexed as

Candida albicansFungal ProteinsMembrane Transport ProteinsAdenosine TriphosphateAmino Acid SubstitutionAntifungal AgentsBiological TransportDrug Resistance, FungalSaccharomyces cerevisiaeAdenosine TriphosphateAntifungal AgentsCDR1 protein, Candida albicansFungal ProteinsMembrane Transport ProteinsABC transporterCandida albicansCdr1efflux mechanismefflux pump inhibitorentry gatemultidrug resistancePDR transporter

Identifiers

PMID41744681
PMCPMC13059742

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.