Evidence map›Paper›PMID 41744676›Full record

ReviewBiology2026

Beyond BMI: Nutritional Recovery and Functional Implications of CFTR Modulators in Cystic Fibrosis.

Giovanna Linguiti, Vanja Granberg, Giuseppina Leonetti, Giuseppe Lassandro, Marisa Lassandro, Maurizio Delvecchio, Paola Giordano

Abstract readReview
In one paragraph

Review in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Multi-omics identification of amino acid and redox dysregulation in cystic fibrosis-related diabetes.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Giovanna LinguitiPediatric Unit "B. Trambusti", Cystic Fibrosis Regional Reference Center, Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0001-9840-1790
Vanja GranbergPediatric Unit "B. Trambusti", Cystic Fibrosis Regional Reference Center, Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
Giuseppina LeonettiPediatric Unit "B. Trambusti", Cystic Fibrosis Regional Reference Center, Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
Giuseppe LassandroPediatric Unit "B. Trambusti", Cystic Fibrosis Regional Reference Center, Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
Marisa LassandroPediatric Unit "B. Trambusti", Cystic Fibrosis Regional Reference Center, Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
Maurizio DelvecchioDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0002-1528-0012
Paola GiordanoPediatric Unit "B. Trambusti", Cystic Fibrosis Regional Reference Center, Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cystic fibrosis (CF) is a multisystem genetic disorder in which malnutrition has historically been a major determinant of disease severity. The advent of CFTR modulators has significantly altered the nutritional and functional profile of CF patients. This systematic review, conducted following PRISMA guidelines and registered on PROSPERO, summarizes studies published from 2012 to 2025 that evaluated the impact of CFTR modulators on nutritional status, body composition, and respiratory function, with a particular focus on the relationship between BMI changes and FEV

Indexed as

body compositionbody mass indexcystic fibrosiselexacaftor/tezacaftor/ivacaftorivacaftornutritionobesity

Identifiers

PMID41744676
PMCPMC12937645

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.