ArticleBiomimetics (Basel, Switzerland)2026
Comparison of the Caries Remineralizing Effects of Dentifrices Based on Natural Hydroxyapatite, Synthetic Hydroxyapatite, and Fluoride: A pH Cycling Study.
Article in Biomimetics (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIn vitro study compared the efficacy in remineralizing initial caries of dentifrice containing natural hydroxyapatite (natHAP), synthetic HAP (synHAP), and fluoride.
methodsInitial carious lesions were created on 105 bovine enamel blocks by 4-day demineralization in a microbial caries model inoculated and fed 3× daily with 10% sucrose (6 min/episode). The caries-bearing blocks were stratified across seven treatment groups (N = 15/group); 20% nat-nHAP tooth powder, 20% nat-nHAP toothpaste, 30% nat-nHAP toothpaste, 20% nat-microHAP toothpaste, 15% syn-nHAP, fluoride (1100 ppm) toothpaste (NaF), and artificial saliva (AS) were used, and the groups were subjected to 28-day remineralization using a standardized pH cycling model with a daily regimen consisting of three 2 min toothpaste slurry treatments and one 2 h acidic challenge, and AS storage for the rest of the day. Surface microhardness of each block was measured after demineralization and after remineralization. Statistical analyses were performed using a paired
resultsAll groups induced significant (
conclusionsWithin the limitations of the present in vitro study, dentifrices based on natHAP or synHAP have comparable efficacy to standard fluoride toothpaste in remineralizing initial caries.
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