Evidence map›Paper›PMID 41744475›Full record

ArticleEpilepsia2026

Lactate receptor HCAR1 in neonatal hypoxic-ischemic seizures.

Jennifer Burnsed, Angelina June, Maria Marlicz, Emmy Zucker, Ellie Kain-Kuzniewski, Hannah Mulhern, Leanne Maharaj, John Williamson, Chengsan Sun, Suchitra Joshi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jennifer BurnsedDepartment of Pediatrics, University of Virginia, Charlottesville, Virginia, USA.ORCID https://orcid.org/0000-0002-1902-1499
Angelina JuneDepartment of Pediatrics, University of Virginia, Charlottesville, Virginia, USA.ORCID https://orcid.org/0000-0002-1992-6909
Maria MarliczDepartment of Pediatrics, University of Virginia, Charlottesville, Virginia, USA.ORCID https://orcid.org/0009-0004-4285-612X
Emmy ZuckerCollege of Arts and Sciences, University of Virginia, Charlottesville, Virginia, USA.
Ellie Kain-KuzniewskiCollege of Arts and Sciences, University of Virginia, Charlottesville, Virginia, USA.
Hannah MulhernDepartment of Pediatrics, University of Virginia, Charlottesville, Virginia, USA.
Leanne MaharajCollege of Arts and Sciences, University of Virginia, Charlottesville, Virginia, USA.
John WilliamsonDepartment of Neurology, University of Virginia, Charlottesville, Virginia, USA.
Chengsan SunDepartment of Neurology, University of Virginia, Charlottesville, Virginia, USA.ORCID https://orcid.org/0009-0002-6429-7846
Suchitra JoshiDepartment of Neurology, University of Virginia, Charlottesville, Virginia, USA.ORCID https://orcid.org/0000-0003-3524-2061
Huayu SunDepartment of Neurology, University of Virginia, Charlottesville, Virginia, USA.
Jaideep KapurDepartment of Neurology, University of Virginia, Charlottesville, Virginia, USA.ORCID https://orcid.org/0000-0002-8608-1352

Funding

Secondarily generalized tonic clonic seizure; a functional anatomyR37NS119012 · NINDS · UNIVERSITY OF VIRGINIA · PI Jaideep Kapur · 2021 to 2026
$3.4M
Motor cortex plasticity in temporal lobe epilepsyR01NS120945 · NINDS · UNIVERSITY OF VIRGINIA · PI KAPUR, JAIDEEP · 2021 to 2025
$2.5M
Progesterone receptor regulation of seizuresR01NS110863 · NINDS · UNIVERSITY OF VIRGINIA · PI JOSHI, SUCHITRA · 2019 to 2023
$1.8M
Brain Institute, University of VirginiaNIH HHS R01 NS120945NIH HHS R37NS11901NINDS NIH HHS R01 NS110863NINDS NIH HHS R01 NS120945NINDS NIH HHS R37 NS119012School of Medicine, University of Virginia
6 · The paper itself

Abstract

Hydroxycarboxylic acid receptor 1 (HCAR1) is a G-protein-coupled lactate receptor expressed in the brain and plays a role in neuronal excitability and repair after injury. Hypoxic-ischemic encephalopathy (HIE) is the most common cause of brain injury and seizures in term neonates. The goal of this study was to describe HCAR1 expression and function in the neonatal brain and understand its role in HIE-associated seizures. HCAR1 expression was measured using quantitative reverse transcriptase polymerase chain reaction in postnatal day (p)10-50 mice. Neuronal properties and spontaneous excitatory postsynaptic currents (sEPSCs) were measured in hippocampal principal neurons from HCAR1 knockout and wild-type mice when exposed to lactate. p10 HCAR1 knockout and wild-type mice were exposed to hypoxia-ischemia (HI) and underwent electroencephalography to compare seizure burden. HCAR1 was expressed at p10 at similar levels to adults. Lactate decreased amplitudes and sEPSC frequency in wild-type but not HCAR1 knockout mice. After HI, HCAR1 knockout mice had higher seizure burden and behavioral seizure scores than wild-type mice. HCAR1 is expressed on neurons and plays a role in neuronal excitability and seizures in the neonatal brain.

Indexed as

HippocampusHypoxia-Ischemia, BrainReceptors, G-Protein-CoupledSeizuresAnimalsAnimals, NewbornDisease Models, AnimalElectroencephalographyExcitatory Postsynaptic PotentialsLactic AcidMaleMiceMice, Inbred C57BLMice, KnockoutNeuronsHcar1 protein, mouseLactic AcidReceptors, G-Protein-CoupledHCAR1hydroxycarboxylic acid receptor 1hypoxia–ischemialactateneonatalseizures

Identifiers

PMID41744475
PMCPMC13075599

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.