ArticleActa odontologica latinoamericana : AOL2025
Midpalatal suture expansion: an in vivo histological and immunohistochemical study of the impact of force magnitude.
Article in Acta odontologica latinoamericana : AOL, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
introductionAlthough there is sufficient clinical evidence regarding the effectiveness of rapid expansion of the middle palate, some of the biological responses to variables such as the magnitude of the expansive force are still unknown.
aimThe aim of this study was to conduct a qualitative and quantitative analysis of the response of midpalatal suture tissues in growing rats exposed to expansive forces of different magnitudes. MATERIALS AND
methodTwenty-four 7-week-old male Wistar rats were divided into 3 groups: a control group (C) and two experimental groups to which 60 g or 90 g expansive forces were applied for 7 days (E60 and E90, respectively). Frontal sections of the upper maxillae were stained with haematoxylin-eosin, Masson's trichrome and PAS-Alcian Blue. The expression of runt related transcription factor 2 (Runx2) and receptor activator of nuclear factor kappa B ligand (RANKL) was evaluated by immunohistochemical staining.
resultsThe degree of expansion and the biological response of the cells involved in the suture ossification process were evaluated histomorphometrically. ANOVA was used for statistical comparisons. Both the expansive forces applied caused significant increases in maxillary width and suture area. Group E60 showed qualitative changes in the composition of the cartilage extracellular matrix, a significant increase in the percentage of Runx2+ mesenchymal like cells, and a significant reduction in the number of RANKL+ chondrocytes/mm2.
conclusionsThese results show that lower expansive forces would stimulate osteogenesis in a direct manner not associated to the endochondral ossification of suture secondary cartilage, enabling partial elucidation of how bone resorption and formation are regulated during rapid maxillary expansion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.