ArticleJournal of the American Heart Association2026
Misperception in Heart Failure Phenotyping: Moving Beyond the Chamber to the Myocardium.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeft ventricular ejection fraction (LVEF) remains the cornerstone of heart failure (HF) phenotyping, yet it weakly correlates with outcomes and may overestimate systolic function, especially in elderly women with altered left ventricular geometry. We evaluated the limitations of conventional LVEF-based phenotyping, assessed sex-specific differences in left ventricular geometry, and tested whether geometry-adjusted LVEF or left ventricular global longitudinal strain (LVGLS) improves prognostic performance.
methodsWe retrospectively analyzed 3688 patients (53.0% men; median age, 70 years) hospitalized for acute HF from the STRATS-AHF (Strain for Risk Assessment and Therapeutic Strategies in Patients With Acute Heart Failure) multicenter registry (2009-2016). Population distributions of LVEF, LVGLS, and a geometry-adjusted index (iLVEF
resultsWomen showed a bimodal distribution of LVEF and a steeper age-related increase compared with men, accompanied by higher relative wall thickness. In contrast, both iLVEF
conclusionsLVEF may overestimate systolic function in concentric remodeling, particularly in elderly women. Geometry-adjusted iLVEF
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