Evidence map›Paper›PMID 41744110›Full record

ArticleJournal of the American Heart Association2026

Sex-Related Differences in Clinical Profile, Management, and Outcomes of Patients With Type A and B Acute Aortic Dissection: Observations From IRAD.

Elizabeth Jackson, Andreina Carbone, Sherene Shalhub, Chih-Wen Pai, Marek Ehrlich, Toru Suzuki, G Chad Hughes, Anil Bhan, Rumi Faizer, Antonio Cittadini and 5 more

Abstract readComparative StudyMulticenter Study
In one paragraph

Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Journal of the American Heart Association · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Elizabeth Jackson *Division of Cardiovascular Disease University of Alabama at Birmingham Birmingham AL USA.ORCID 0000-0002-5086-0418
Andreina Carbone *Unit of Cardiology University of Campania "Luigi Vanvitelli" Naples Italy.ORCID 0000-0002-2190-7010
Sherene ShalhubDepartment of Anesthesiology University of Washington School of Medicine Seattle WA USA.ORCID 0000-0002-8501-2750
Chih-Wen PaiDivision of Cardiovascular Medicine, Department of Internal Medicine University of Michigan Ann Arbor MI USA.ORCID 0000-0003-0983-5947
Marek EhrlichDepartment of Cardiac Surgery Medical University of Vienna Vienna Austria.ORCID 0000-0002-1114-5788
Toru SuzukiDepartment of Cardiovascular Sciences University of Leicester, BHF Cardiovascular Research Centre, Glenfield Hospital Leicester UK.ORCID 0000-0002-8371-664X
G Chad HughesDivision of Cardiovascular and Thoracic Surgery, Department of Surgery Duke University Medical Center Durham NC USA.ORCID 0000-0002-8960-3785
Anil BhanDepartment of Cardiac Surgery Medanta The Medicity Gurgaon Haryana India.
Rumi FaizerDivision of Vascular Surgery University of Minnesota Minneapolis MN USA.ORCID 0000-0002-4633-3527
Antonio CittadiniDepartment of Translational Medical Sciences Federico II University Naples Italy.
Alan BravermanDepartment of Medicine, Cardiovascular Division Washington University School of Medicine St. Louis MO USA.ORCID 0000-0003-1859-310X
Eric IsselbacherCorrigan Minehan Heart Center, Massachusetts General Hospital Harvard Medical School Boston MA USA.ORCID 0000-0003-0393-168X
Kim EagleDepartment of Internal Medicine University of Michigan Health System Ann Arbor MI USA.ORCID 0000-0003-0031-0191
Christoph Nienaber *Department of Cardiology Royal Brompton and Harefield Trust London UK.ORCID 0000-0001-9671-8030
Eduardo Bossone *Department of Public Health University of Naples "Federico II" Naples Italy.ORCID 0000-0003-2769-9950

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAvailable data about sex differences in patients with acute aortic dissection (AAD) are scant and conflicting. The aim of this study is to assess sex-related differences in clinical characteristics, presentation, diagnostic findings, management, and outcomes among patients with type A (TA-AAD) and type B AAD (TB-AAD).

methodsData about 11 586 patients enrolled in the IRAD (International Registry of Acute Aortic Dissection) from 1996 to 2022, were analyzed; 7819 (67.5%) experienced TA-AAD and 3867 (33.0%) TB-AAD. Men and women were compared with regard to diagnosis, treatment, and in-hospital and long-term survival.

resultsOne third of patients were women (TA-AAD, 34.4%; and TB-AAD, 34.5%). Women were older than men for both types of AAD. The median time from hospital admission to diagnosis was longer in women for both TA-AAD and TB-AAD (

conclusionsThe present study highlights important sex-related differences in AAD; there is a need to design tailored aortic disease management programs to improve outcomes in women.

Indexed as

Aortic DissectionAcute DiseaseAgedDissection, Ascending AortaDissection, Thoracic AortaFemaleHospital MortalityHumansMaleMiddle AgedRegistriesRisk FactorsSex FactorsTime FactorsTreatment Outcomeacute aortic dissectionaortasex differencestype A acute aortic dissectiontype B acute aortic dissection

Identifiers

PMID41744110
PMCPMC13055758

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.