Evidence map›Paper›PMID 41744107›Full record

ArticleJournal of the American Heart Association2026

Heightened Risk of Myocardial Ischemia With Mental Stress Among Black Women Survivors of a Myocardial Infarction in Midlife.

Viola Vaccarino, Amit J Shah, Tené T Lewis, Marina Piccinelli, Lisa Elon, Hua She, Yi-An Ko, Zachary T Martin, Nancy Murrah, Lucy Shallenberger and 6 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Journal of the American Heart Association · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Viola VaccarinoDepartment of Epidemiology, Rollins School of Public Health Emory University Atlanta GA USA.ORCID 0000-0002-9054-0654
Amit J ShahDepartment of Epidemiology, Rollins School of Public Health Emory University Atlanta GA USA.ORCID 0000-0001-9099-9687
Tené T LewisDepartment of Epidemiology, Rollins School of Public Health Emory University Atlanta GA USA.ORCID 0000-0003-3905-8931
Marina PiccinelliDepartment of Radiology Emory University School of Medicine Atlanta GA USA.
Lisa ElonDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health Emory University Atlanta GA USA.ORCID 0000-0003-2307-6617
Hua SheDepartment of Epidemiology, Rollins School of Public Health Emory University Atlanta GA USA.
Yi-An KoDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health Emory University Atlanta GA USA.ORCID 0000-0002-6543-9765
Zachary T MartinDepartment of Epidemiology, Rollins School of Public Health Emory University Atlanta GA USA.ORCID 0000-0002-1746-312X
Nancy MurrahDepartment of Epidemiology, Rollins School of Public Health Emory University Atlanta GA USA.ORCID 0000-0002-9333-3781
Lucy ShallenbergerDepartment of Epidemiology, Rollins School of Public Health Emory University Atlanta GA USA.ORCID 0000-0002-6868-6956
Tatum RobertsDepartment of Epidemiology, Rollins School of Public Health Emory University Atlanta GA USA.
Lewam StefanosDepartment of Epidemiology, Rollins School of Public Health Emory University Atlanta GA USA.
Eric Fan-LouDepartment of Epidemiology, Rollins School of Public Health Emory University Atlanta GA USA.
J Douglas BremnerAtlanta VA Medical Center Decatur GA USA.ORCID 0000-0003-1633-6433
Paolo RaggiDepartment of Epidemiology, Rollins School of Public Health Emory University Atlanta GA USA.ORCID 0000-0002-5766-1948
Arshed QuyyumiDepartment of Medicine, Division of Cardiology Emory University School of Medicine Atlanta GA USA.ORCID 0000-0002-8166-679X

Funding

Vascular Responses During Mental StressP01HL101398 · NHLBI · EMORY UNIVERSITY · PI BREMNER, JAMES DOUGLAS · 2010 to 2015
$11.0M
Mental Stress and Myocardial Ischemia after MI: Sex Differences, Mechanisms and PrognosisR01HL109413 · NHLBI · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 2012 to 2023
$6.9M
Multidisciplinary Research Training to Reduce Inequities in Cardiovascular HealthT32HL130025 · NHLBI · EMORY UNIVERSITY · PI Tené T Lewis, Viola Vaccarino · 2016 to 2026
$6.4M
Mind-Body Interactions in Cardiovascular DiseaseK24HL077506 · NHLBI · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 2004 to 2013
$1.5M
Biological Correlates of Traumatic StressK24MH076955 · NIMH · EMORY UNIVERSITY · PI BREMNER, JAMES DOUGLAS · 2006 to 2013
$946k
Emotional Stress as a Risk Factor for Arrhythmia: Ischemic and Genetic MechanismsK23HL127251 · NHLBI · EMORY UNIVERSITY · PI SHAH, AMIT JASVANT · 2016 to 2019
$749k
NHLBI NIH HHS K23 HL127251NHLBI NIH HHS K24 HL077506NHLBI NIH HHS P01 HL101398NHLBI NIH HHS R01 HL109413NHLBI NIH HHS T32 HL130025NIMH NIH HHS K24 MH076955
6 · The paper itself

Abstract

backgroundStark disparities in the outcome of myocardial infarction (MI) persist, with large unexplained variations affecting younger Black women. Mental stress-induced myocardial ischemia (MSIMI) is an emerging mechanistic pathway that may help explain excess risks in this group. We sought to determine whether MSIMI is more common in Black women with recent premature MI than other demographic groups.

methodsWe cross-sectionally studied 602 individuals 61 years and younger who were hospitalized for MI in the previous 8 months. Participants underwent 99mTc-sestamibi myocardial perfusion imaging at rest and after mental stress (speech task). A summed difference score was used to quantify ischemia. Clinically significant MSIMI was defined as a summed difference score ≥3. Log-binomial and robust Poisson regression were used to adjust for sociodemographic, lifestyle, clinical, and psychosocial factors.

resultsThe mean age of patients was 51 years (range, 25-61 years), 46% were women, and 59% self-identified as Black. Black women had a more adverse psychosocial profile and higher rates of obesity and diabetes but a less severe index MI. The incidence of MSIMI was approximately doubled in Black women than the other groups (

conclusionsAmong midlife individuals with a recent MI, Black women have a disproportionately higher risk of MSIMI. Targeted interventions for this high-risk group are needed.

Indexed as

Black or African AmericanMyocardial InfarctionMyocardial IschemiaStress, PsychologicalAdultCross-Sectional StudiesFemaleHumansIncidenceMiddle AgedMyocardial Perfusion ImagingRisk AssessmentRisk Factorscoronary artery diseasemental stressmyocardial ischemiapsychological factorsrace differencessex differences

Identifiers

PMID41744107
PMCPMC13055664

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.