Evidence map›Paper›PMID 41744106›Full record

Observational studyJournal of the American Heart Association2026

Spontaneous Coronary Artery Dissection: Sex Differences in Clinical Presentation and Outcomes From the Australian New Zealand Registry.

Fergal T Temple, Quan Dang, Sonya Burgess, Swati Mukherjee, Jaya Chandrasekhar, Peter J Psaltis, Leonard Kritharides, Nigel Jepson, Mithila Zaheen, Patrick Pender and 19 more

Abstract readComparative StudyMulticenter StudyObservational Study
In one paragraph

Observational study in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Journal of the American Heart Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Fergal T TempleSydney Medical School University of Sydney Australia.ORCID 0000-0003-0497-2694
Quan DangWestmead Applied Research Centre University of Sydney Australia.ORCID 0000-0003-0309-1289
Sonya BurgessSydney Medical School University of Sydney Australia.ORCID 0000-0001-5262-3064
Swati MukherjeeDepartment of Cardiology Cabrini Hospital Malvern Australia.
Jaya ChandrasekharDepartment of Cardiology Box Hill Hospital Melbourne Australia.ORCID 0000-0001-8776-326X
Peter J PsaltisAdelaide Medical School The University of Adelaide Australia.ORCID 0000-0003-0222-5468
Leonard KritharidesSydney Medical School University of Sydney Australia.ORCID 0000-0001-5818-8024
Nigel JepsonDepartment of Cardiology Prince of Wales Hospital Sydney Australia.ORCID 0000-0003-4403-8273
Mithila ZaheenWestmead Applied Research Centre University of Sydney Australia.
Patrick PenderWestmead Applied Research Centre University of Sydney Australia.
Sarah FairleyDepartment of Cardiology Wellington Hospital Wellington New Zealand.ORCID 0000-0001-9200-8218
Abdul IhdayhidDepartment of Cardiology Fiona Stanley Hospital Perth Australia.ORCID 0000-0003-0501-0980
Jamie LaylandDepartment of Cardiology Frankston Hospital Melbourne Australia.
Richard SzirtDepartment of Cardiology St George Hospital Sydney Australia.ORCID 0000-0002-6352-6777
Seif El-JackCardiovascular Unit North Shore Hospital Waitematā New Zealand.
Aniket PuriDepartment of Cardiology Christchurch Hospital Christchurch New Zealand.
Esther DavisVictorian Heart Institute Monash University Melbourne Australia.
Imran ShiekhDepartment of Cardiology Royal Perth Hospital Perth Australia.
Ruth ArnoldOrange Base Hospital Orange Australia.
Monique WattsDepartment of Cardiology Alfred Hospital Melbourne Australia.ORCID 0009-0001-3881-8954
Hui Zhen LoUniversity of Melbourne Australia.ORCID 0009-0007-3785-3911
Jessica A MaratheSydney Medical School University of Sydney Australia.
Rohan BhagwandeenCardiology Department John Hunter Hospital Newcastle Australia.
Edwina Wing-LunSydney Medical School University of Sydney Australia.
Ravinay BhindiDepartment of Cardiology Royal North Shore Hospital Sydney Australia.
Thomas J FordThe University of Newcastle - Central Coast Clinical School Gosford Australia.ORCID 0000-0003-4009-6652
Sidney LoDepartment of Cardiology Liverpool Hospital Sydney Australia.ORCID 0000-0002-9624-7301
Simone MarschnerWestmead Applied Research Centre University of Sydney Australia.ORCID 0000-0002-5484-9144
Sarah ZamanWestmead Applied Research Centre University of Sydney Australia.ORCID 0000-0001-6289-583X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSpontaneous coronary artery dissection (SCAD) predominantly affects women with limited data in men. We aimed to determine sex differences in SCAD presentation, associated conditions, and major adverse cardiovascular events (MACE).

methodsCohort study of 23 ANZ-SCAD sites (Australian/New Zealand Registry, data previously published) with core laboratory confirmed SCAD. Descriptive statistics for sex differences. Interaction analysis with Cox proportional hazards model assessed the effect of sex on previously published independent predictors of MACE.

resultsOf a total of 527 patients with SCAD, 468 (88.8%) were female. Mean age was similar, at 53.5±10.6 in women and 52.2±10.7 in men. Women had higher rates of hypertension (30.6% versus 16.9% men,

conclusionsWomen with SCAD had higher rates of hypertension, coronary tortuosity, and FMD, whereas men had more non-FMD vascular abnormalities. Self-reported emotional stress was common, equally prevalent in women and men. Anticoagulation, dual antiplatelet therapy, FMD, and previous stroke were independent predictors of MACE in both women and men. REGISTRATION: URL: https://anzctr.org.au/; Unique Identifier: 12621000824864.

Indexed as

Coronary Vessel AnomaliesVascular DiseasesAdultAgedAustraliaDissection, Blood VesselFemaleHumansHypertensionMaleMiddle AgedNew ZealandPlatelet Aggregation InhibitorsRegistriesRisk AssessmentRisk FactorsPlatelet Aggregation Inhibitorscoronary angiographycoronary vesselspercutaneous coronary intervention

Identifiers

PMID41744106
PMCPMC13055690

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.