Evidence map›Paper›PMID 41743982›Full record

ArticlebioRxiv : the preprint server for biology2026

Identification and Evaluation of dibasic piperidines as novel cell wall inhibitors against

Claire Naylor, Gareth A Prosser, Tracy Bayliss, Lila Berle, Joshua B Wallach, Heather Kim, Rodrigo Aguilera Olvera, Stephen Thompson, Thomas R Ioerger, Laura Simpson and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Claire NaylorDrug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.
Gareth A ProsserDrug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.ORCID 0000-0002-3586-0284
Tracy BaylissDrug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.
Lila BerleTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, 9000 Rockville Pike, Bethesda, Maryland, MD 20892, USA.ORCID 0009-0001-3642-1793
Joshua B WallachDept. of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA.ORCID 0009-0002-1108-3852
Heather KimDept. of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA.ORCID 0000-0003-3152-5785
Rodrigo Aguilera OlveraDept. of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA.ORCID 0000-0001-5762-8470
Stephen ThompsonDrug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.
Thomas R IoergerDepartment of Computer Science and Engineering, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0001-8702-9102
Laura SimpsonDrug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.
Ruth CasanuevaGlobal Health Medicines R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760, Madrid, Spain.
Laura Guijarro-LopezGlobal Health Medicines R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760, Madrid, Spain.
Kevin D ReadDrug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.ORCID 0000-0002-8536-0130
Paul G WyattDrug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.ORCID 0000-0002-0397-245X
Dirk SchnappingerDept. of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA.ORCID 0000-0002-4445-7219
Clifton E BarryTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, 9000 Rockville Pike, Bethesda, Maryland, MD 20892, USA.ORCID 0000-0002-2927-270X
Simon R GreenDrug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.ORCID 0000-0001-5054-4792
Helena I BoshoffTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, 9000 Rockville Pike, Bethesda, Maryland, MD 20892, USA.ORCID 0000-0002-4333-206X
Laura A T CleghornDrug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.ORCID 0000-0001-6218-0092

Funding

Bill & Melinda Gates Foundation INV-001727Bill & Melinda Gates Foundation INV-002178Bill & Melinda Gates Foundation INV-002563
6 · The paper itself

Abstract

Globally,

Indexed as

antibioticsdi-basic serieshigh-throughput screeningMycobacterium tuberculosisphenotypic drug discoverytarget elucidation

Identifiers

PMID41743982
PMCPMC12930433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.