Acute hemiplegia as initial presentation in FIP1L1-PDGFRA-rearranged myeloid neoplasm with eosinophilia: a case report.

Min Cheng, Wenjie Shi, Jin Xu, Doudou Wei, Yue Sun, Qian Jiang, Yongjie Li

Abstract readCase Reports

In one paragraph

Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Min Cheng *Department of Neurology, People's Hospital, Peking University, Beijing, China.

Wenjie Shi *Department of Neurology, People's Hospital, Peking University, Beijing, China.

Jin XuDepartment of Neurology, People's Hospital, Peking University, Beijing, China.

Doudou WeiDepartment of Neurology, Jishan County People's Hospital of Shanxi Province, Shanxi, China.

Yue SunDepartment of Neurology, People's Hospital, Peking University, Beijing, China.

Qian JiangBeijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, China.

Yongjie LiDepartment of Neurology, People's Hospital, Peking University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Myeloid neoplasms harboring the FIP1L1-PDGFRA Case presentation: A 27-year-old man presented with acute hemiplegia and was found to have significant eosinophilia. Neuroimaging revealed acute-subacute infarcts with concurrent focal stenosis of the right middle cerebral artery. He was diagnosed with F/P-rearranged myeloid neoplasm associated with myeloid sarcoma. Treatment with low-dose imatinib monotherapy (100 mg/day) resulted in rapid resolution of both eosinophilia and the vascular stenosis. Over 9 years of follow-up without adjuvant antithrombotic agents, he has maintained sustained molecular remission and normal neurological function, with no recurrent stroke. Conclusion: This case provides new clinical data for the diagnosis and treatment of this type of eosinophilia, and highlights the importance of early recognition, workup, and treatment. Peripheral hypereosinophilia may cause tissue damage, leading to hypereosinophilic syndrome with cerebral infarction.

Indexed as

case reporteosinophiliaFIP1L1-PDGFRAimatinibmyeloid tumors

Identifiers

PMID41743957

DOI10.3389/fonc.2026.1628690

PMCPMC12929143

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