ArticleFrontiers in neuroscience2026
Carotid intraplaque neovascularization increases the risk of white matter hyperintensity progression: a prospective cohort study.
Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and purpose: White matter hyperintensities (WMH) are a common imaging manifestation of cerebral small vessel disease (CSVD). While carotid intraplaque neovascularization (IPN) has been implicated in WMH burden, its longitudinal impact on WMH progression, particularly across different brain regions, remains to be fully elucidated. Methods: We conducted a longitudinal cohort study of patients with baseline WMH, who underwent carotid IPN grading (Grade 0-2) via AngioPLUS ultrasound. Clinical demographics, vascular risk factors, and key laboratory parameters (including homocysteine and LDL-C) were collected. WMH progression was defined as an increase in the total score of the visual Rotterdam Progression Scale (range: -7 to +7) by ≥1 point on follow-up MRI, indicating new or enlarged lesions. Logistic regression analysis was used to determine the relationship between IPN and progression of white matter hyperintensities. Results: In this longitudinal cohort study, a total of 213 patients (mean age 71.0 ± 8.9 years; 56.8% male) were included in the final analysis. Over a mean follow-up period of 17.8 months (range: 4-52 months), overall progression of white matter hyperintensities (WMH) was observed in 124 patients (58.2%). Specifically, progression of periventricular WMH (PWMH) and deep WMH (DWMH) occurred in 42.3 and 33.8% of patients, respectively. Patients with WMH progression showed a significantly higher prevalence of vascular risk factors compared to those without progression. Logistic regression analysis, after adjustment for age, smoking, alcohol consumption, hypertension, diabetes, history of stroke, body mass index, low-density lipoprotein cholesterol, and follow-up duration, indicated that grade 2 (high-grade) intraplaque neovascularization in the carotid artery was independently associated with the progression of deep white matter hyperintensities (OR 2.06, 95% CI 1.05-4.05). Conclusion: Carotid intraplaque neovascularization is an independent predictor of deep WMH progression. Assessing plaque vulnerability via IPN grading may help identify patients at high risk for progressive white matter injury and serve as a potential target for therapeutic intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.