Evidence map›Paper›PMID 41743852›Full record

ArticleResearch (Washington, D.C.)2026

Targeting a Shared Mitophagy Regulator: The SIRT1-FOXO3-DEPP1 Axis Underpins the Dual Bone and Brain Benefits of Total Flavonoids from

Yili Zhang, Xiangyun Guo, Qing Wang, Long Xiao, Qingqing Liu, Yiwen Gan, Yunning Li, Chuanrui Sun, Zhiwen Luo, Kai Sun and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yili ZhangSchool of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China.
Xiangyun GuoSchool of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China.
Qing WangDepartment of Orthopaedics, Kunshan Hospital of Chinese Medicine, Suzhou 215300, Jiangsu, China.
Long XiaoTranslational Medical Innovation Center, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou 215600, Jiangsu, China.
Qingqing LiuSchool of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China.
Yiwen GanSchool of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China.
Yunning LiSchool of Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China.
Chuanrui SunWangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China.
Zhiwen LuoDepartment of Sports Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.ORCID https://orcid.org/0000-0002-0524-9951
Kai SunWangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China.
Weiwei TaoSchool of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China.
Xu WeiWangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postmenopausal osteoporosis and depression often occur together, but a single treatment that improves both conditions is currently lacking. The loss of estrogen can trigger oxidative stress, damage mitochondria, and drive dysregulated autophagy with impaired flux, simultaneously harming bone and the brain. We evaluated whether total flavonoids from

Identifiers

PMID41743852
PMCPMC12929817

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.