Evidence map›Paper›PMID 41743848›Full record

ArticleResearch (Washington, D.C.)2026

Origin of Single-Molecule Reaction Chirality.

Chen Yang, Shuyao Zhou, Yilin Guo, Xinmiao Xie, Ju Wang, Yanwei Li, Jingyuan Hu, Linghai Xie, Zhirong Liu, Guangwu Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chen YangBeijing National Laboratory for Molecular Sciences, National Biomedical Imaging Center, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China.
Shuyao ZhouBeijing National Laboratory for Molecular Sciences, National Biomedical Imaging Center, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China.
Yilin GuoBeijing National Laboratory for Molecular Sciences, National Biomedical Imaging Center, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China.ORCID https://orcid.org/https://orcid.org/0009-0003-9401
Xinmiao XieBeijing National Laboratory for Molecular Sciences, National Biomedical Imaging Center, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China.
Ju WangCenter of Single-Molecule Sciences, Institute of Modern Optics, Frontiers Science Center for New Organic Matter, College of Electronic Information and Optical Engineering, Nankai University, Tianjin 300350, P. R. China.
Yanwei LiEnvironment Research Institute, Shandong University, Qingdao, P. R. China.ORCID https://orcid.org/https://orcid.org/0000-0003-4089
Jingyuan HuInstitute of Chemistry, Henan Academy of Sciences, Zhengzhou 450046, P. R. China.
Linghai XieCenter for Molecular Systems and Organic Devices, Key Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials, Nanjing University of Posts & Telecommunications, Nanjing 210023, P. R. China.ORCID https://orcid.org/https://orcid.org/0000-0001-6294
Zhirong LiuBeijing National Laboratory for Molecular Sciences, National Biomedical Imaging Center, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China.ORCID https://orcid.org/https://orcid.org/0000-0001-5070
Guangwu LiCenter of Single-Molecule Sciences, Institute of Modern Optics, Frontiers Science Center for New Organic Matter, College of Electronic Information and Optical Engineering, Nankai University, Tianjin 300350, P. R. China.ORCID https://orcid.org/https://orcid.org/0000-0002-7387
Xuefeng GuoBeijing National Laboratory for Molecular Sciences, National Biomedical Imaging Center, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China.ORCID https://orcid.org/0000-0001-5723-8528

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The origin of molecular chirality remains an enigma in chemistry, particularly regarding how single-molecule events overcome intrinsic stochasticity to establish population-level chirality. Here, we present a viable strategy for real-time, from-the-beginning single-molecule trajectory monitoring of asymmetric evolution from a single initial molecule with single-event resolution, allowing direct observation of spontaneous mirror symmetry breaking in a single-molecule Diels-Alder reaction system. We monitor the asymmetric evolution in real time using the chirality-induced spin selectivity effect. This approach enables the capture of initial symmetry breaking at the single-molecule level and the identification of the excess-compensation mechanism. In addition, the introduction of an external electric field to the symmetry-breaking species enables universal asymmetric synthesis without the need for a catalyst. The increase in the number of molecules leads to symmetry breaking, which is also contingent on the coupling with the external environment. This work deepens our understanding of the molecular principles underlying the origin of life and has many implications for precise chiral synthesis and drug design.

Identifiers

PMID41743848
PMCPMC12929813

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.