Evidence map›Paper›PMID 41743836›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)

Autonomic dysfunction and hypothalamic atrophy in frontotemporal dementia and primary psychiatric disorders.

Yannick S S Timar, Marie-Paule Emilie van Engelen, Vikram Venkatraghavan, Benjamin Billot, Jay Lydia Petronella Fieldhouse, Jochum J Van't Hooft, Sterre C M de Boer, Chris S Koevoets, Luc W Hartog, Collin Groot and 5 more

Abstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yannick S S TimarAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc Amsterdam the Netherlands.
Marie-Paule Emilie van EngelenAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc Amsterdam the Netherlands.
Vikram VenkatraghavanAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc Amsterdam the Netherlands.
Benjamin BillotInria, Université Côte d'Azur, Epione team, Sophia-Antipolis Valbonne France.
Jay Lydia Petronella FieldhouseAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc Amsterdam the Netherlands.
Jochum J Van't HooftAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc Amsterdam the Netherlands.
Sterre C M de BoerAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc Amsterdam the Netherlands.
Chris S KoevoetsAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc Amsterdam the Netherlands.
Luc W HartogAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc Amsterdam the Netherlands.
Collin GrootDepartment of Radiology & Nuclear Medicine Amsterdam UMC Vrije Universiteit Amsterdam the Netherlands.
Mardien L OudegaAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc Amsterdam the Netherlands.
Jort Everard G B VijverbergAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc Amsterdam the Netherlands.
Wiesje M van der FlierAmsterdam Neuroscience, Neurodegeneration, Alzheimer Center Amsterdam, Department of Neurology Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC Amsterdam the Netherlands.
Frederik BarkhofDepartment of Radiology & Nuclear Medicine Amsterdam UMC Vrije Universiteit Amsterdam the Netherlands.
Yolande A L PijnenburgAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc Amsterdam the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionEvidence suggests that autonomic symptoms in frontotemporal dementia (FTD) may relate to hypothalamic pathology. We investigated (1) autonomic symptoms in FTD, primary psychiatric disorders (PPD), and controls; (2) hypothalamic volumes; and (3) their associations.

methodsAutonomic Symptoms Questionnaire (ASQ) data were collected from FTD (

resultsFTD and PPD groups reported more cardiovascular symptoms than controls ( DISCUSSION: FTD patients exhibit increased autonomic symptoms across several domains compared to PPD and controls; moreover, FTD is associated with smaller regional hypothalamic volume.

Indexed as

autonomic dysfunctionautonomic nervous systemfrontotemporal dementiahypothalamic degenerationhypothalamusneurodegenerationprimary psychiatric disorders

Identifiers

PMID41743836
PMCPMC12929029

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.