ArticleInternational journal of genomics2026
Circulating Metabolic Factors Mediating the Effect of Obesity-Related Indicators on Meniscal Injuries: A Mendelian Randomization Study.
Article in International journal of genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Circulating Metabolic Factors Mediating the Effect of Obesity-Related Indicators on Meniscal Injuries: A Mendelian Randomization Study.International journal of genomics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Meniscal injuries and obesity are major global public health problems. The Mendelian randomization approach can overcome the limitations of traditional observational study designs with respect to confounding and reverse causation. The aims of the current study are to assess the causal relationship between obesity-related indicators and meniscal injuries using MR analyses and to explore the potential underlying mechanism. Methods: In total, seven obesity-related indicators and 11 circulating metabolic indicators were downloaded as instrumental variables from published genome-wide association studies (GWAS), and the meniscal injury data from the FinnGen database was used as the outcome indicators. The causal relationships and mediating factors were analyzed using two-sample univariate MR, multivariate MR, and intermediate MR. Results: After applying the Bonferroni correction, the IVW model indicated that five obesity-related indicators, namely, waist circumference ( Conclusions: Our study suggests that increases in serum uric acid levels, driven by body fat percentage, may increase the risk of meniscal injuries. We hope that these findings will provide new insights for the prevention and treatment of meniscal injury.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.