ArticleFrontiers in immunology2026
Peripheral blood B-cell compartment dysregulation in multidrug-resistant tuberculosis is associated with reduced circulating marginal zone-like B cells.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Multidrug-resistant tuberculosis (MDR-TB) remains a major global health challenge. While T cell-mediated immunity in tuberculosis is well characterized, alterations in circulating B-cell subsets during chronic MDR-TB are less well defined. Methods: Peripheral blood mononuclear cells (PBMCs) from healthy controls [interferon gamma release assay negative (IGRA Results: Frequencies of major T-cell and natural killer (NK)-cell populations were broadly similar across groups. In contrast, patients with ATB showed a reduction in total CD19 Conclusion: MDR-TB is associated with broad perturbations of the peripheral B-cell compartment, including reduced ASCs and decreased circulating MZ B cells. These findings highlight B-cell dysregulation as a feature of active disease and identify MZ B cells as a subset of interest for further investigation rather than as a stand-alone diagnostic marker.
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