ArticleFrontiers in immunology2026
Case Report: Pemphigus following COVID-19 mRNA vaccination: two cases achieving long-term remission without relapse.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Autoimmune blistering diseases (AIBDs) are mediated by autoantibodies targeting structural proteins of the epidermis or dermo-epidermal junction. Since the introduction of COVID-19 mRNA vaccines, isolated cases of pemphigus temporally associated with vaccination have been described, although causal relationships remain uncertain. We report two patients who developed pemphigus following COVID-19 mRNA vaccination and showed an exceptionally favorable clinical course. A 66-year-old man developed pemphigus foliaceus one week after his second vaccine dose, and a 45-year-old woman developed pemphigus vulgaris two months after her second dose. Both patients responded promptly to corticosteroid therapy, with normalization of autoantibody titers and achievement of long-term complete remission lasting over two years without relapse or maintenance therapy. These outcomes stand in contrast to sporadic pemphigus, which usually follows a chronic relapsing course, and suggest that vaccine-related pemphigus may, in rare instances, represent a transient and self-limited immune dysregulation. Such cases are exceptional and should not discourage COVID-19 vaccination.
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