ReviewFrontiers in reproductive health2026
Unraveling molecular heterogeneity: a systematic review of susceptibility gene profiles in ovarian, deep infiltrating, and superficial peritoneal endometriosis.
Review in Frontiers in reproductive health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Endometriosis is a heterogeneous gynecological disease manifesting in three distinct phenotypes: superficial peritoneal endometriosis (SUP), ovarian endometrioma (OMA), and deep infiltrating endometriosis (DIE). While Genome-Wide Association Studies (GWAS) have identified numerous susceptibility loci-such as Objectives: This systematic review aims to analyze the differential activation and expression patterns of known endometriosis-susceptibility genes across SUP, OMA, and DIE to determine if distinct genetic signatures define each phenotype. Methods: A systematic search was conducted in PubMed, Scopus, and Embase up to September 2025. We included observational case-control and cohort studies comparing the mRNA or protein expression of GWAS-identified susceptibility genes in ectopic endometrial tissue, stratified by phenotype. Quality assessment was performed using the Newcastle-Ottawa Scale (NOS). Results: A total of 15 studies involving 1,240 tissue samples were included in the final synthesis. The analysis revealed significant heterogeneity in gene activation. Genes associated with cell adhesion and invasion (e.g., Conclusion: Endometriosis phenotypes are not merely anatomical variations but represent biologically distinct entities driven by unique gene activation profiles. These findings support a move toward phenotype-specific molecular diagnostics and targeted therapies.
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