Evidence map›Paper›PMID 41743603›Full record

ArticlePlastic and reconstructive surgery. Global open2026

Balanced Restoration: Optimizing Midface Rejuvenation Using Hyaluronic Acid Fillers.

Rod J Rohrich, Raul Cetto, Conor J Gallagher, David Weir, David A Hollander, Jessica Brown, Kevin Wu

Abstract read
In one paragraph

Article in Plastic and reconstructive surgery. Global open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rod J RohrichFrom the Dallas Plastic Surgery Institute, Dallas, TX.
Raul CettoLe Petit Saint, London, United Kingdom.
Conor J GallagherRevance Therapeutics, Inc., Nashville, TN.
David WeirFrom the Dallas Plastic Surgery Institute, Dallas, TX.
David A HollanderAndover Eye, Andover, MA.
Jessica BrownRevance Therapeutics, Inc., Nashville, TN.
Kevin WuRevance Therapeutics, Inc., Nashville, TN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently available hyaluronic acid filler technologies concentrate on reflation of the aging midface primarily with the use of fillers to reinflate the deep fat compartments. However, filler technology has evolved, which allows us to reconsider how to address midface volume loss more appropriately. We propose that balanced restoration, a multilayered technique, should be the contemporary approach to midface revolumization with hyaluronic acid fillers, as it is based on an advanced understanding of anatomy and can achieve natural-looking outcomes that maintain dynamic facial expression. The midface comprises 2 distinct fat layers, superficial and deep, with different morphological and mechanical attributes that reflect the different functions that fat tissue plays in each layer. Because of the more dynamic nature of the superficial fat layer over the more static deep fat layer, and its roles in providing facial contours and permitting skin mobility and facial expression, multilayered techniques for balanced restoration involve selecting appropriate products that match the viscoelastic properties of the fat that is being replaced. Reflation of the superficial fat compartments requires fillers with cohesivity and more dynamic properties than deep fillers to enable adaptation to facial movement and to provide natural outcomes. Here, we summarize the advances in the understanding of the anatomical considerations for midface rejuvenation and provide guidance on how to differentiate superficial fat loss from deep fat loss and on how to select the most appropriate injectable hyaluronic acid fillers to achieve balanced restoration in patients requiring midface rejuvenation.

Identifiers

PMID41743603
PMCPMC12931948

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.