Evidence map›Paper›PMID 41743589›Full record

ArticleComputational toxicology (Amsterdam, Netherlands)2025

Development of the toxicity values database, ToxValDB: A curated resource for experimental and derived human health-relevant toxicity data.

Jonathan T Wall, Risa R Sayre, Doris Smith, Samuel Winter, Maxwell Groover, Jasmine Hope, Adriana Webb, Katie Paul Friedman, Madison Feshuk, Antony J Williams and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational toxicology (Amsterdam, Netherlands), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. AI/ML-based computational models for toxicity prediction.Environmental science and pollution research international · 2026
    Review
  2. Review
  3. Perspectives on variability ofFrontiers in toxicology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jonathan T WallCenter for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.ORCID 0000-0002-4610-8645
Risa R SayreCenter for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.ORCID 0000-0002-6173-8020
Doris SmithCenter for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
Samuel WinterCenter for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
Maxwell GrooverCenter for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.ORCID 0009-0007-7234-4194
Jasmine HopeCenter for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
Adriana WebbCenter for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
Katie Paul FriedmanCenter for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.ORCID 0000-0002-2710-1691
Madison FeshukCenter for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.ORCID 0000-0002-1390-6405
Antony J WilliamsCenter for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.ORCID 0000-0002-2668-4821
Charles LoweCenter for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.ORCID 0000-0001-9151-6157
Nisha S SipesCenter for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.ORCID 0000-0003-4203-6426
Jason LambertCenter for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
Jennifer H OlkerCenter for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.ORCID 0000-0002-7877-4773
Russell S ThomasCenter for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
Colleen ElonenCenter for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
Richard S JudsonCenter for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.ORCID 0000-0002-2348-9633
Chelsea A WeitekampCenter for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.ORCID 0000-0001-6392-7784

Funding

Intramural EPA EPA999999
6 · The paper itself

Abstract

The Toxicity Values Database, ToxValDB, was developed by the U.S. EPA Center for Computational Toxicology and Exposure as a resource to curate, store, standardize, and make accessible a wide range of human health-relevant toxicity information. The database originated in response to the need for harmonized and computationally accessible toxicology data. The scope and design of the database have evolved over time since its first release in 2016. Herein, the newly redesigned structure and development of ToxValDB v9.6.1 is described. The database is a compilation of three classes of summary-level values for chemical substances:

Indexed as

Human health assessmentNew approach methodsPredictionValidation

Identifiers

PMID41743589
PMCPMC12931138

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.