ArticleEcology and evolution2026
Evolutionary History of the Adult β-Globin Gene in Wild Sheep: First Sequences From the Argali (
Article in Ecology and evolution, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The β-globin gene cluster is a key model for studying molecular adaptation and gene family evolution in vertebrates, exhibiting dynamic duplication and deletion events in ruminants, particularly within the subfamily Caprinae. However, the complete nucleotide sequences of the adult β-globin gene remain unknown for several ecologically important wild sheep species, such as the Argali and the Urial, hindering robust phylogenetic and adaptive studies. Genomic DNA was extracted from wild Argali and Urial samples, and the full coding region of the adult β-globin gene was sequenced and compared against a comprehensive dataset of Bovidae and Cervidae. Sequence comparison confirmed high divergence between paralogous genes (HBBA and HBBB), and critically, revealed that Argali hosts two distinct adult β-globin haplotypes, one harboring a HBBA gene and the other a HBBB gene. Phylogenetic analysis revealed that sequences clustered consistently by paralog type (HBBA vs. HBBB) with both the Caprinae and Bovinae lineages. This pattern suggests independent evolutionary trajectories for each paralog, likely driven by concerted evolution. Molecular dating estimated the duplication event leading to the HBBA/HBBB paralogs in Caprinae at approximately 2.55 million years ago, supporting a rapid, recent diversification of the β-globin cluster in
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