ArticleFrontiers in veterinary science2026
Cerebrospinal fluid markers and magnetic resonance imaging lesion volume predicting relapse in canine meningoencephalitis of unknown origin.
Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Meningoencephalitis of unknown origin (MUO) is a potentially lethal neurological disease in dogs with a high relapse rate. Prognostic factors for relapse based on neurological examination, magnetic resonance imaging (MRI), or cerebrospinal fluid (CSF) examination are inconsistently reported. Methods: This retrospective single center study included 35 dogs with MUO. Brain MRI, CSF findings, clinical signs at diagnosis and during follow-up MRI (routine or relapse-related) were analyzed. Lesion volumes were calculated using the Cavalieri method. Relapse predictors were evaluated for routine follow- up MRI examinations using logistic regression and ROC/AUC. Result: Only higher CSF albumin ( Discussion: In this study, CSF albumin and lymphocyte proportion were identified as predictors of future relapse. Routine follow-up MRI was not predictive of future relapse, but useful for detection of an active inflammation.
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