ArticleFrontiers in endocrinology2026
Infants exposed to maternal type 1 diabetes: intrauterine epigenetic modifications and neurological development.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Targeted 3.34-Million CpG Site Sequencing Reveals Preliminary Cord Blood Epigenetic Alterations of Autism Spectrum Disorder: A Pilot Study Highlighting theInternational journal of molecular sciences · 2026Article
- Association Between Maternal Gestational Diabetes, Cord Blood DNA Methylation, and Offspring Neurodevelopment.International journal of molecular sciences · 2026Article
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Authors and funding
14 authors.
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Abstract
Background: The relationship between the neurodevelopment in infants exposed to maternal Type-1 diabetes and changes in fetal DNA methylation has not yet been investigated. Aim: This hypothesis-generating study, we aimed to determine whether neurodevelopmental outcomes in offspring from mothers with Type-1 diabetes are associated with intrauterine epigenetic changes in fetal DNA. Material and Methods: We conducted a prospective, pilot case-control study, comparing infants exposed to maternal Type-1-diabetes with control infants. Cord blood DNA samples were analyzed using the TruSeq-Methyl-Capture-EPIC-Kit, covering over 3.3 million CpGs. The Bayley-III Scales were used to assess infant neurodevelopment, and the scores were correlated with the newborn DNA methylation data. Results: In infants exposed to maternal diabetes, we identified 108 differentially methylated genes enriched in pathways crucial for neurodevelopment: Vocal, Imitative and Observational Learning, Synapse Organization, and Neurogenesis. The greatest methylation differences were observed in differentially methylated regions (DMRs) annotated to key neurological genes: Conclusions: While further confirmation is needed, we provide the first results supporting the hypothesis that neurodevelopmental alterations observed in offspring of mothers with Type-1 diabetes are potentially associated with DNA methylation changes during intrauterine life which can be identified at birth.
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