ArticleArtificial intelligence review2026
Topological data analysis and topological deep learning beyond persistent homology: a review.
Article in Artificial intelligence review, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- CAKR: commutative algebra k-mer representations for genomics.Nature communications · 2026Article
- Persistent sheaf Laplacian analysis of protein stability and solubility changes upon mutation.Protein science : a publication of the Protein Society · 2026Article
- Article
- Correlated clustering and projection for dimensionality reduction.Machine learning: science and technology · 2026Article
- Commutative Algebra Modeling in Materials Science - A Case Study on Metal-Organic Frameworks (MOFs).Journal of chemical information and modeling · 2026Article
- Computational Drug Repurposing for Alzheimer's Disease via Sheaf Theoretic Population-Scale Analysis of snRNA-Seq Data.Journal of medicinal chemistry · 2026Article
- Predicting protein-nucleic acid flexibility using persistent sheaf Laplacians.Physical chemistry chemical physics : PCCP · 2026Article
- Interpretability and Representability of Commutative Algebra, Algebraic Topology, and Topological Spectral Theory for Real-World Data.Advanced intelligent discovery · 2025Article
- A Review of Topological Data Analysis and Topological Deep Learning in Molecular Sciences.Journal of chemical information and modeling · 2025Review
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Topological data analysis (TDA) is a rapidly evolving field in applied mathematics and data science that leverages tools from topology to uncover robust, shape-driven, and explainable insights in complex datasets. The main workhorse is persistent homology, a technique rooted in algebraic topology. Paired with topological deep learning (TDL) or topological machine learning, persistent homology has achieved tremendous success in a wide variety of applications in science, engineering, medicine, and industry. However, persistent homology has many limitations due to its high-level abstraction, insensitivity to non-topological changes, and restriction to point cloud data. This paper presents a comprehensive review of TDA and TDL beyond persistent homology. It analyzes how persistent topological Laplacians and Dirac operators provide spectral representations to capture both topological invariants and homotopic evolution. Other formulations are presented in terms of sheaf theory, Mayer topology, and interaction topology. For data on differentiable manifolds, techniques rooted in differential topology, such as persistent de Rham cohomology, persistent Hodge Laplacian, and Hodge decomposition, are reviewed. For one-dimensional (1D) curves embedded in 3-space, approaches from geometric topology are discussed, including multiscale Gauss-link integrals, persistent Jones polynomials, and persistent Khovanov homology. This paper further discusses the appropriate selection of topological tools for different input data, such as point clouds, sequential data, data on manifolds, curves embedded in 3-space, and data with additional non-geometric information. A review is also given of various topological representations, software packages, and machine learning vectorizations. Finally, this review ends with concluding remarks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.