Evidence map›Paper›PMID 41743488›Full record

ArticleArtificial intelligence review2026

Topological data analysis and topological deep learning beyond persistent homology: a review.

Zhe Su, Xiang Liu, Layal Bou Hamdan, Vasileios Maroulas, Jie Wu, Gunnar Carlsson, Guo-Wei Wei

Abstract read
In one paragraph

Article in Artificial intelligence review, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Correlated clustering and projection for dimensionality reduction.Machine learning: science and technology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhe SuDepartment of Mathematics and Statistics, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0003-3499-6814
Xiang LiuDepartment of Mathematics, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0001-6046-1405
Layal Bou HamdanDepartment of Mathematics, University of Tennessee, Knoxville, TN 37996-1320, USA.
Vasileios MaroulasDepartment of Mathematics, University of Tennessee, Knoxville, TN 37996-1320, USA.ORCID 0000-0002-3412-6766
Jie WuBeijing Institute of Mathematical Sciences and Applications, Beijing 101408, China.ORCID 0000-0003-2445-6750
Gunnar CarlssonDepartment of Mathematics, Stanford University, Stanford, CA 94305, USA.
Guo-Wei WeiDepartment of Mathematics, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0002-5781-2937

Funding

AI-based platform for predicting emerging vaccine-escape variants and designing mutation-proof antibodiesR01AI164266 · NIAID · UNIVERSITY OF GEORGIA · PI Guowei Wei, YONG-HUI ZHENG · 2022 to 2026
$2.7M
Discovery-Driven Mathematics and Artificial Intelligence for Biosciences and Drug DiscoveryR35GM148196 · NIGMS · UNIVERSITY OF GEORGIA · PI Guowei Wei · 2023 to 2026
$1.5M
NIAID NIH HHS R01 AI164266NIGMS NIH HHS R35 GM148196
6 · The paper itself

Abstract

Topological data analysis (TDA) is a rapidly evolving field in applied mathematics and data science that leverages tools from topology to uncover robust, shape-driven, and explainable insights in complex datasets. The main workhorse is persistent homology, a technique rooted in algebraic topology. Paired with topological deep learning (TDL) or topological machine learning, persistent homology has achieved tremendous success in a wide variety of applications in science, engineering, medicine, and industry. However, persistent homology has many limitations due to its high-level abstraction, insensitivity to non-topological changes, and restriction to point cloud data. This paper presents a comprehensive review of TDA and TDL beyond persistent homology. It analyzes how persistent topological Laplacians and Dirac operators provide spectral representations to capture both topological invariants and homotopic evolution. Other formulations are presented in terms of sheaf theory, Mayer topology, and interaction topology. For data on differentiable manifolds, techniques rooted in differential topology, such as persistent de Rham cohomology, persistent Hodge Laplacian, and Hodge decomposition, are reviewed. For one-dimensional (1D) curves embedded in 3-space, approaches from geometric topology are discussed, including multiscale Gauss-link integrals, persistent Jones polynomials, and persistent Khovanov homology. This paper further discusses the appropriate selection of topological tools for different input data, such as point clouds, sequential data, data on manifolds, curves embedded in 3-space, and data with additional non-geometric information. A review is also given of various topological representations, software packages, and machine learning vectorizations. Finally, this review ends with concluding remarks.

Indexed as

55-0857K1857R1962R40Algebraic TopologyDifferential TopologyGeometric TopologyTopological Data AnalysisTopological Deep LearningTopological Spectrum Theory

Identifiers

PMID41743488
PMCPMC12931839

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.