Evidence map›Paper›PMID 41743481›Full record

ArticleFrontiers in public health2026

WiraChain: a blockchain and FHIR-based platform for improving clinical data interoperability in healthcare.

Leonardo Grau, Joao Urrunaga, José Santisteban

Abstract read
In one paragraph

Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Leonardo GrauSoftware Engineering, Universidad Peruana de Ciencias Aplicadas, (UPC), Lima, Peru.
Joao UrrunagaInformation Systems Engineering, Universidad Peruana de Ciencias Aplicadas, (UPC), Lima, Peru.
José SantistebanInformation Systems Engineering, Universidad Peruana de Ciencias Aplicadas, (UPC), Lima, Peru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interoperability challenges in healthcare frequently lead to fragmented patient records and duplicated procedures, negatively affecting continuity of care and operational efficiency. Although multiple theoretical frameworks and standards have been proposed to address these issues, practical and fully implemented solutions enabling secure and controlled data exchange remain limited. To address this gap, we developed Wirachain, a decentralized application that integrates blockchain technology with the HL7 FHIR standard for electronic health record management. The system enables patient-controlled permission granting and revocation, incorporates authentication and role-based access control, and supports persistent storage using both FHIR-compliant and traditional databases. Validation was conducted using synthetically generated clinical data and stress-testing scenarios to assess system performance under load. The results demonstrate that the proposed application can reliably manage access permissions and clinical data exchange across interoperable components. The system maintained efficient operation and secure data handling under simulated clinical workflows and increased load conditions. These findings indicate that fully implemented blockchain-based solutions can effectively bridge the gap between conceptual interoperability frameworks and practical healthcare applications. Wirachain illustrates the feasibility of combining blockchain and FHIR standards to support secure, patient-centered, and interoperable clinical operations.

Indexed as

BlockchainElectronic Health RecordsHealth Information InteroperabilityHealth Level SevenComputer SecurityDigital HealthHumansblockchainelectronic health recordsEthereumHL7 FHIRHyperledgerinteroperabilitysmart contract

Identifiers

PMID41743481
PMCPMC12929507

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.