ArticleFrontiers in public health2026
Construction and validation of a nomogram based on clinical indicators for 28-day composite poor prognosis prediction in severe sepsis.
Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To develop and internally validate an individualized nomogram integrating intestinal barrier-specific biomarkers and systemic clinical indicators to help assess intestinal barrier function and provide a reference for prognosis prediction in patients with severe sepsis. Methods: Three hundred fifty-two patients with severe sepsis admitted between January 2022 and December 2024 were continuously enrolled and randomly divided into training ( Results: Baseline characteristics did not differ significantly between sets (all Conclusion: The constructed nomogram, incorporating intestinal barrier biomarkers and systemic clinical indicators, can help assess intestinal barrier-related risk and provide a reference for predicting adverse outcomes in severe sepsis. It offers a valuable decision-support tool for early goal-directed intervention and demonstrates significant clinical translational potential.
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