Evidence map›Paper›PMID 41743330›Full record

ArticleResearch square2026

Time-Dependent Effects of Rapid-Acting Antidepressants in iPSC-Derived Neurons from Treatment-Resistant Depression and Healthy Volunteers.

Jenessa Johnston, Greg Jones, Shiyong Peng, Peixiong Yuan, Mani Yavi, Bashkim Kadriu, Ioline Henter, Brandi Quintanilla, Abdel G Elkahloun, Ruin Moaddel and 5 more

Registry-linked trialAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02484456 (An Investigation of the Antidepressant Effects of the Glycine Receptor Antagonist AV 101), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02484456 phase2completednot on this map

An Investigation of the Antidepressant Effects of the Glycine Receptor Antagonist AV 101 (4-chlorokynurenine) in Major Depressive Disorder

TypeinterventionalSponsorNational Institute of Mental Health (NIMH)Ran2015 to 2019Enrolled22ConditionsMajor DepressionArmsAV 101 (4-Chlorokynurenine), Placebo Comparator
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Jenessa JohnstonNIMH.
Greg Jones
Shiyong PengNational Institute of Mental Health.
Peixiong YuanNIH.
Mani YaviNational Institute of Mental Health.
Bashkim KadriuNIMH-NIH.ORCID https://orcid.org/0000-0002-3809-9451
Ioline Henter
Brandi QuintanillaUniversity of Texas Health Science Center at Houston.
Abdel G ElkahlounNational Human Genome Research Institute.
Ruin Moaddel
Anton SchulmannNational Institute of Mental Health.ORCID https://orcid.org/0000-0002-6323-4969
Nirmala AkulaNational Institutes of Mental Health, NIH.
Mark KvartaNational Institute of Mental Health/NIH.ORCID https://orcid.org/0000-0002-1093-1648
Francis McMahonNational Institute of Mental Health Intramural Research Program; National Institutes of Health.ORCID https://orcid.org/0000-0002-9469-305X
Carlos ZarateNIMH.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rapid-acting antidepressants like ketamine and serotonergic psychedelics show promise for treatment-resistant depression (TRD), but the molecular mechanisms that contribute to their therapeutic effects remain unclear. Induced pluripotent stem cells (iPSCs) offer a platform to model human cortical neurons and investigate drug effects in a human-relevant system. Here, iPSCs from individuals with TRD and healthy volunteers (HVs) were differentiated into mature cortical-like neurons and treated for six and 24 hours with agents being investigated as rapid-acting antidepressants, including (2 Clinical Trial Registry: www.clinicaltrials.gov, NCT02484456.

Identifiers

PMID41743330
PMCPMC12930440

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.