ArticleFrontiers in pharmacology2026
Evaluating a multifaceted stewardship intervention on proton pump inhibitor utilization: an interrupted time-series analysis of prescribing patterns in a northwest Chinese hospital.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Impact of an IV proton pump inhibitor restriction policy on prescribing patterns and estimated drug cost.Frontiers in pharmacology · 2026Article
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5 authors.
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Abstract
Background: Promoting the rational use of proton pump inhibitors (PPIs) has become an important aspect in controlling the growth of pharmaceutical expenditures in China. In recent years, the first national guidelines for the clinical application of PPIs and the second batch of the China National Key Monitoring Drug (NKMD) policy were released to regulate PPI utilization. However, few studies have fully investigated the impact of the multifaceted stewardship intervention on PPI utilization in hospitals, especially in northwestern China. Methods: We collected monthly PPI usage data over 8 years from a tertiary hospital of northwestern China between January 2017 and December 2024. Multi-intervention interrupted time-series (ITS) analysis was used to evaluate the change in the defined daily dose (DDD) per 100 bed-days under the intervention measures managed by clinical pharmacists through the multifaceted stewardship. Results: Although the DDD per 100 bed-days for overall PPIs decreased by 12.93 ( Conclusion: The implementation of the national guidelines led to a significant immediate reduction, but no significant time trend in the overall PPI utilization was observed. Our findings highlight the impact of the NKMD policy on the sustained downward trend in overall and oral PPI consumption. The prospective prescription review system may be effective in promoting the long-term rational use of PPIs in clinical practice.
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