Evidence map›Paper›PMID 41743104›Full record

ArticleFrontiers in medicine2026

Self-medication with proton pump inhibitors among physicians in Bosnia and Herzegovina: a cross-sectional study.

Predrag Jovanovic, Goran Bokan, Mirela Basic Denjagic, Nermin Salkic, Admir Kurtcehajic, Aleksandar Gavric, Kenana Ljuca, Mario Tadic, Rusmir Mesihovic, Goran Hauser and 1 more

Abstract read
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Predrag JovanovicDepartment of Gastroenterology and Hepatology, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina.
Goran BokanInternal Medicine Clinic, Department of Gastroenterology and Hepatology, University Clinical Centre of the Republic of Srpska, Banja Luka, Bosnia and Herzegovina.
Mirela Basic DenjagicDepartment of Gastroenterology and Hepatology, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina.
Nermin SalkicDepartment of Gastroenterology and Hepatology, University Medical Center Ljubljana, Ljubljana, Slovenia.
Admir KurtcehajicDepartment of Gastroenterology and Hepatology, Medical Center Plava Poliklinika, Tuzla, Bosnia and Herzegovina.
Aleksandar GavricDepartment of Gastroenterology and Hepatology, University Medical Center Ljubljana, Ljubljana, Slovenia.
Kenana LjucaDepartment of Gynecology and Obstetrics, University Clinical Center Ljubljana, Ljubljana, Slovenia.
Mario TadicFaculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.
Rusmir MesihovicMerus Medicinski Center, Ljubljana, Slovenia.
Goran HauserDepartment of Gastroenterology, CHC Rijeka, Rijeka, Croatia.
Dina ZeremCantonal Hospital "Dr. Safet Mujic," Mostar, Bosnia and Herzegovina.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Proton pump inhibitors (PPIs) are widely used for the treatment of acid-related disorders, but inappropriate or prolonged use carries potential health risks. Physicians, due to their access to medication and clinical knowledge, may be prone to self-medicating with PPIs without appropriate oversight. Objective: To assess the prevalence and patterns of personal PPI use and self-medication among practicing physicians in Bosnia and Herzegovina, and to identify demographic and professional predictors of such behavior. Methods: A cross-sectional, questionnaire-based survey was conducted among 448 physicians who responded to the study invitation, out of approximately 600 invited, from various healthcare levels in Bosnia and Herzegovina between January and May 2025. The survey collected data on PPI use history, consultation behavior, awareness of adverse effects, and adherence to treatment guidelines. Multivariable logistic regression was used to identify independent predictors of self-medication. Results: A total of 65.4% of respondents reported past PPI use, during their medical practice, and 31.7% were current users. Over half (52.2%) admitted using PPIs without consulting another physician, and only 17.4% referred to clinical guidelines prior to use. Occasional use was the most common pattern (59.0%), while adverse effects were rarely reported (1.8%). No demographic or professional variable was significantly associated with self-medication with PPIs (defined as PPI use without consulting another physician) in the multivariable analysis. Conclusion: Self-medication with PPIs is highly prevalent among physicians and frequently occurs without clinical consultation or adherence to guidelines. This behavior appears to be widespread across age groups, sexes, and care levels, highlighting the need for institutional interventions that promote rational prescribing and raise awareness about responsible self-care within the medical profession.

Indexed as

cross-sectional studyphysiciansprescribing behaviorproton pump inhibitorsreal-world evidenceself-medication

Identifiers

PMID41743104
PMCPMC12929428

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.