Evidence map›Paper›PMID 41743047›Full record

SynthesisFrontiers in neurology

Stem cell therapy for ischemic stroke: neuroimaging approaches and evidence from a systematic review.

Bin Jiang, Moss Zhao, Elizabeth Tong, Yongkai Liu, Ates Fettahoglu, Wen-Kai Weng, Michael E Moseley, Max Wintermark, Gary K Steinberg, Greg Zaharchuk

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bin JiangDepartment of Radiology, School of Medicine, Stanford University, Stanford, CA, United States.
Moss ZhaoDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, CA, United States.
Elizabeth TongDepartment of Radiology, School of Medicine, Stanford University, Stanford, CA, United States.
Yongkai LiuDepartment of Radiology, School of Medicine, Stanford University, Stanford, CA, United States.
Ates FettahogluDepartment of Radiology, School of Medicine, Stanford University, Stanford, CA, United States.
Wen-Kai WengDepartment of Medicine - Med/Blood and Marrow Transplantation, School of Medicine, Stanford University, Stanford, CA, United States.
Michael E MoseleyDepartment of Radiology, School of Medicine, Stanford University, Stanford, CA, United States.
Max WintermarkDepartment of Neuroradiology, MD Anderson Center, The University of Texas, Houston, TX, United States.
Gary K SteinbergDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, CA, United States.
Greg ZaharchukDepartment of Radiology, School of Medicine, Stanford University, Stanford, CA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Cell-based therapy is a promising approach for ischemic stroke treatment. This systematic review and meta-analysis aimed to consolidate clinical evidence on the use of neuroimaging to evaluate stem cell therapy across all stages of stroke recovery. Methods: A systematic search was conducted in 5 databases in July 2025. They were included if neuroimaging analysis, regardless of cell source, route administration or dosage were reported. The level of evidence and risk of bias were assessed using the ROB-2 or ROBINS-I tool. Imaging data from all included articles were extracted, and randomized-effect meta-analyses were performed when two or more outcomes were available for any reported imaging parameter. Results: Thirty articles were included in the systematic review, of which four were eligible for meta-analysis. Meta-analysis of subacute stroke patients revealed no significant differences in infarct volume reduction at 3 months (SMD = -0.50; 95% CI: -1.15 to 0.51; Conclusion: Advanced neuroimaging offers a valuable non-invasive tool for assessing the effects of stem cell therapy in ischemic stroke. However, substantial heterogeneity in imaging protocols and reporting limits cross-study comparisons. Standardization of neuroimaging methodology is essential to advance future research and clinical translation.

Indexed as

brainimagingischemic strokeMRIPETstem cell

Identifiers

PMID41743047
PMCPMC12931286

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.