ArticleFrontiers in neuroscience2025
Frequency tagged multifocal pupillary response fields identify age-related macular degeneration and diabetic retinopathy.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: To quickly characterize multifocal Pupillary Response Fields (mPRF) using frequency tagging and to identify pupillary biomarkers of age-related macular degeneration (AMD) and diabetic retinopathy (DR). Methods: Participants with AMD ( Analyses: The recorded pupillary traces were corrected for blinks and transient artifacts. Features of pupillary dynamics and eye-movements, - eye instability during fixation, pupil light reflex, and spectral components of pupil oscillations - were compared across groups. Statistical analyses were performed for each feature separately using Student t-tests and Cohen's Results: Multifocal Pupillary Response Fields (mPRF) derived from regional spectral power and phase distributions differed significantly between patients and controls, in accordance with the characteristics of each pathology: decreased power for central and paracentral sectors in AMD, diffuse defects in DR. AUCs of ROC performed with relevant features achieved excellent sensitivity (>0.9) and specificity (>0.9) in classifying patients from healthy subjects. Conclusion: Fast, objective, and easily recorded, mPRF assessments evaluate the functional integrity of retino-pupillary circuits, providing spatiotemporal bio-signatures selective for maculopathies and retinopathies.
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