Prognostic Value of Hemoglobin, Albumin, Lymphocyte, and Platelet Score in Predicting Mortality in Patients With Aortic Dissection: A Retrospective Single-Center Study Based on ROC Curve Analysis.

Background: Aortic dissection (AD) is a life-threatening cardiovascular emergency associated with high mortality. Early risk stratification through reliable biomarkers is critical for guiding clinical decisions. The hemoglobin, albumin, lymphocyte, and platelet (HALP) score is a novel composite index reflecting inflammation, nutritional status, and hematologic balance. Although it has shown prognostic relevance in several disease states, its utility in predicting mortality in AD remains unknown. This study aimed to investigate the prognostic value of the HALP score and other hematologic markers in patients with AD. Methods: This retrospective study included 51 patients diagnosed with AD between January 2020 and December 2024 using contrast-enhanced thoracoabdominal computed tomography. Patients were grouped as survivors or nonsurvivors. Hematologic parameters (hemoglobin, hematocrit, red blood cell, platelet count, and mean platelet volume) and inflammatory indices (neutrophil-to-lymphocyte ratio [NLR], platelet-to-lymphocyte ratio [PLR], systemic immune-inflammation index [SII], and HALP score) were recorded. The Shapiro-Wilk test assessed normality; Student's Results: Overall mortality was 33.3%. Nonsurvivors were older and had significantly lower levels of hemoglobin, hematocrit, RBC, and platelet count ( Conclusions: The HALP score demonstrated high specificity and moderate sensitivity in predicting mortality in AD, suggesting its potential as a complementary biomarker. Its ease of use and accessibility make it suitable for emergency clinical settings. Prospective multicenter studies are needed to confirm its prognostic validity and routine application in AD management.