Evidence map›Paper›PMID 41742931›Full record

ArticleFrontiers in microbiomes2024

Immune-reactive tumor organoids system to determine the effects of microbial metabolites on cancer immunity and immunotherapies.

Azza M El-Derby, Cecilia R Schaaf, Ethan Shelkey, Katherine L Cook, Konstantinos I Votanopoulos, Shay Soker

Abstract read
In one paragraph

Article in Frontiers in microbiomes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Azza M El-DerbyWake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, United States.
Cecilia R SchaafWake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, United States.
Ethan ShelkeyWake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, United States.
Katherine L CookDepartment of Cancer Biology, Wake Forest School of Medicine, Winston Salem, NC, United States.
Konstantinos I VotanopoulosWake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, United States.
Shay SokerWake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, United States.

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Consumer-based meditation app, Calm, for treatment of sleep disturbance in hematological cancer patientsR01CA262041 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Jennifer Lynne Huberty, Ruben A. Mesa · 2022 to 2026
$2.8M
NCI NIH HHS P30 CA012197NCI NIH HHS R01 CA262041
6 · The paper itself

Abstract

Immunotherapies are a revolutionary approach to treating cancer by utilizing the body's immune system to target and combat cancer cells. This approach offers promising alternatives to traditional chemotherapies. Its potential to induce long-lasting remissions and specificity for cancer cells, which minimizes side effects, makes it a cutting-edge treatment with tremendous potential. With the increase of the clinical usage of immunotherapy, evidence emerges of the microbiome's impact on both tumor growth and response to immunotherapy. The proposed involvement of the microbiome can change treatment efficacy by altering drug metabolism and reshaping the immune system response. Understanding the specific interactions between tumor cells, immune cells, and the microbiome is a critical step in the advancement of immunotherapy. To study the complex interaction between cancer immunity and the microbiome, various preclinical

Indexed as

cancerhydrogelsimmunotherapyin vitromicrofluidicsorganoid

Identifiers

PMID41742931
PMCPMC12931843

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.