Evidence map›Paper›PMID 41742872›Full record

ArticleHaematologica2026

Three-year safety, efficacy, and renal outcomes of mitapivat treatment in sickle cell disease: results from the phase 2 open-label study.

Geoffrey Z L Kuppens, Maria Armila D Ruiz, Myrthe J Van Dijk, Minke A E Rab, Cleo Derichs, Joline Saes, Anita W Rijneveld, Marjon H Cnossen, Erfan Nur, Bart J Biemond and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Haematologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Geoffrey Z L KuppensCenter for Benign Hematology, Thrombosis and Hemostasis - Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, Utrecht.
Maria Armila D RuizDivision of Hematology/Oncology, University of Illinois Hospital and Health Sciences System, Chicago, IL.
Myrthe J Van DijkCenter for Benign Hematology, Thrombosis and Hemostasis - Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands; Department of Central Diagnostic Laboratory - Research, University Medical Center Utrecht, Utrecht University, Utrecht.
Minke A E RabDepartment of Central Diagnostic Laboratory - Research, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands; Department of Hematology, Erasmus University Medical Center, Rotterdam.
Cleo DerichsCenter for Benign Hematology, Thrombosis and Hemostasis - Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, Utrecht.
Joline SaesCenter for Benign Hematology, Thrombosis and Hemostasis - Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, Utrecht.
Anita W RijneveldDepartment of Hematology, Erasmus University Medical Center, Rotterdam.
Marjon H CnossenDepartment of Pediatric Hematology and Oncology, Erasmus MC Sophia Children's Hospital University Medical Center Rotterdam, Rotterdam.
Erfan NurDepartment of Hematology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam.
Bart J BiemondDepartment of Hematology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam.
Marije BartelsCenter for Benign Hematology, Thrombosis and Hemostasis - Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, Utrecht.
Santosh L SarafDivision of Hematology/Oncology, University of Illinois Hospital and Health Sciences System, Chicago, IL.
Eduard J Van BeersCenter for Benign Hematology, Thrombosis and Hemostasis - Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, Utrecht. e.j.vanbeers-3@umcutrecht.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID41742872
PMCPMC13482238

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.