ArticleInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2026
Day 3 embryo quality predicts clinical pregnancy and live birth rates following single frozen-thawed poor-quality blastocyst transfer.
Article in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis study explored the value of Day 3 embryo quality in selecting blastocysts of the same grade, with a specific focus on poor-quality blastocysts.
methodsThis retrospective study included 734 single frozen-thawed blastocyst transfer cycles from January 2018 to October 2021. Cycles were categorized into four groups based on embryo quality: the G-G group (good-quality blastocysts derived from Day 3 good-quality embryos group, n = 194), the G-P group (good-quality blastocysts derived from Day 3 poor-quality embryos group, n = 230), the P-G group (poor-quality blastocysts derived from Day 3 good-quality embryos group, n = 94), and the P-P group (poor-quality blastocysts derived from Day 3 poor-quality embryos group, n = 216). The role of Day 3 embryo quality in selecting blastocysts for transfer was analyzed.
resultsGood-quality blastocysts derived from Day 3 poor-quality embryos showed comparable pregnancy outcomes to those derived from Day 3 good-quality embryos (clinical pregnancy rates: 63.91% vs. 65.98%; live birth rates: 53.04% vs. 55.15%, respectively; P > 0.05). However, poor-quality blastocysts derived from Day 3 good-quality embryos exhibited significantly higher clinical pregnancy rates (58.51% vs. 37.96%, P < 0.01; odds ratio [OR] 2.006, 95% CI 1.185-3.395, P < 0.05) and live birth rates (52.13% vs. 28.70%, P < 0.001; OR 2.318, 95% CI 1.355-3.966, P < 0.01) than those derived from Day 3 poor-quality embryos. CONCLUSION(S): Day 3 embryo quality predicts clinical pregnancy and live birth rates following single frozen-thawed poor-quality blastocyst transfer. When only poor-quality blastocysts are obtained, selecting one derived from Day 3 good-quality embryo for transfer might shorten the time to achieve a live birth.
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